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Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
Published on: June 13, 2021
Examining the relationship between antenatal anxiety and postnatal depression
Marie-Paule Austin1, Lucy Tully, Gordon Parker
1School of Psychiatry, University of New South Wales and Black Dog Institute, Prince of Wales Hospital, Sydney, Australia. m.austin@unsw.edu.au
Antenatal anxiety, measured by the Brief Measure of Worry Severity (BMWS), significantly predicts postnatal depression (PND). The BMWS demonstrated superior predictive capacity compared to the Speilberger State Trait Anxiety Inventory (STAI).
Area of Science:
- Perinatal mental health
- Psychological assessment
- Anxiety and depression research
Background:
- Antenatal anxiety is a known risk factor for postnatal depression.
- Accurate measurement of antenatal anxiety is challenging.
- Existing anxiety measures may not fully capture perinatal anxiety's impact.
Purpose of the Study:
- To evaluate the Brief Measure of Worry Severity (BMWS) in predicting postnatal depression (PND).
- To assess the psychometric properties of the BMWS in a pregnant population.
- To compare the predictive power of the BMWS against the Speilberger State Trait Anxiety Inventory (STAI) for PND.
Main Methods:
- 748 pregnant women completed the BMWS and STAI in their third trimester.
- The Edinburgh Postnatal Depression Scale (EPDS) was administered at 8 weeks postpartum.
- Statistical analyses controlled for antenatal depression and other confounding factors.
Main Results:
- High antenatal anxiety on the BMWS increased PND likelihood by 2.6 times, even after controlling for covariates.
- The STAI lost its predictive significance for PND after controlling for confounding variables.
- The BMWS showed strong construct validity, correlating with other anxiety and depression measures.
Conclusions:
- The BMWS is a valuable tool for assessing antenatal anxiety in clinical and research settings.
- Antenatal anxiety, as measured by the BMWS, is a significant precursor to PND.
- Potential attrition bias was noted, as non-participants seemed at higher risk for PND.
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