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Related Concept Videos

Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
What is the Skeletal System?01:02

What is the Skeletal System?

Overview
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Essential Minerals for Bone Health01:31

Essential Minerals for Bone Health

The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
The Functions of the Skeletal System01:22

The Functions of the Skeletal System

The most apparent functions of the skeletal system are support, protection, and movement. However, bone tissue also performs several other critical metabolic functions. For one, the bone matrix acts as a reservoir for a number of minerals important to the functioning of the body, especially calcium and phosphorus. These minerals, present in the bone tissue, can be released back into the bloodstream when required. Calcium ions, for example, are essential for muscle contractions and controlling...

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Related Experiment Video

Updated: Jul 18, 2026

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders
11:47

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders

Published on: June 8, 2014

Extra-skeletal effects of bisphosphonates.

Addolorata Corrado1, Nella Santoro, Francesco Paolo Cantatore

  • 1University of Foggia, D'Avanzo Hospital, Via Ascoli 1, 71100 Foggia, Italy. ada_corrado@libero.it

Joint Bone Spine
|January 2, 2007
PubMed
Summary

Bisphosphonates reduce bone resorption by inhibiting osteoclasts. Emerging evidence suggests these drugs also modulate immune responses, potentially benefiting chronic inflammatory joint diseases.

Area of Science:

  • Pharmacology
  • Immunology
  • Rheumatology

Background:

  • Bisphosphonates are established treatments for bone resorption disorders like osteoporosis and Paget's disease.
  • Their primary mechanism involves inhibiting osteoclast activity, reducing bone remodeling.

Purpose of the Study:

  • To explore the extra-skeletal biological effects of bisphosphonates.
  • To investigate the immunomodulatory potential of bisphosphonates.
  • To assess their role in managing chronic joint inflammatory diseases.

Main Methods:

  • Review of clinical and experimental evidence on bisphosphonate effects.
  • Analysis of studies examining bisphosphonate impact on immune cells and cytokine production.
  • Evaluation of data on bisphosphonates in chronic inflammatory joint conditions.

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Cantilever Bending of Murine Femoral Necks
06:44

Cantilever Bending of Murine Femoral Necks

Published on: January 5, 2022

Related Experiment Videos

Last Updated: Jul 18, 2026

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders
11:47

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders

Published on: June 8, 2014

Cantilever Bending of Murine Femoral Necks
06:44

Cantilever Bending of Murine Femoral Necks

Published on: January 5, 2022

Main Results:

  • Bisphosphonates demonstrate effects beyond bone tissue, influencing immune system cells.
  • They exhibit immunomodulatory properties, affecting pro- and anti-inflammatory cytokine production.
  • Evidence suggests potential benefits in controlling chronic joint inflammation.

Conclusions:

  • Bisphosphonates possess significant immunomodulatory effects.
  • Their anti-inflammatory actions may extend their therapeutic applications.
  • Further research is warranted to explore wider clinical use in inflammatory joint diseases.