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Electrochemiluminescence Assays for Human Islet Autoantibodies
Published on: March 23, 2018
Erythroleukaemia, diabetes insipidus and hypophyseal damage: Two case reports
A Piccin1, R Raimondi, S Laspina
1Department of Haematology, S Bortolo Hospital, Vicenza, Italy. andrea.piccin@ibts.ie
Abstract:
We report on two cases of patients who developed diabetes insipidus (DI) before acute erythroleukaemia (EL). A brain MRI showed an empty sella turcica in one case and hypothalamo-hypophyseal peduncle damage in the second case. Reduced levels of TGF-beta1 and Vitamin D3, with associated EVI-1 over-expression and karyotypic abnormalities were documented. These two cases show specific chromosomal/molecular alterations in EL with DI. The hypothesis of pituitary involvement in erythroleukemogenesis is discussed.
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