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Updated: Jul 18, 2026

Purification of the Membrane Compartment for Endoplasmic Reticulum-associated Degradation of Exogenous Antigens in Cross-presentation
Published on: August 21, 2017
Outside looking in: the inner workings of the cross-presentation pathway within dendritic cells
Jose A Villadangos1, William R Heath, Francis R Carbone
1Immunology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville 3050, Australia.
Abstract:
The entry of exogenous antigen into the MHC class I-restricted cross-presentation pathway can contribute to CD8(+) T cell tolerance and immunity, in particular to peripheral self-antigens or selected viruses and bacteria showing restricted tissue tropism. Dendritic cells are the key cross-presenting cells and, as such, they are thought to carry specialized machinery dedicated to this purpose. Two recent papers describe intracellular components tailored to the dendritic cell cross-presentation pathway.
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