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A Protocol for Analyzing Hepatitis C Virus Replication
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The association between hepatitis C infection and prevalent cardiovascular disease among HIV-infected individuals

Matthew S Freiberg1, Debbie M Cheng, Kevin L Kraemer

  • 1Division of General Internal Medicine, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA. freibergms@upmc.edu

AIDS (London, England)
|January 2, 2007
PubMed

Insights

Hepatitis C co-infection significantly increases the odds of cardiovascular disease (CVD) in individuals with HIV. This highlights the importance of managing hepatitis C to reduce CVD risk in this population.

Area of Science:

  • Infectious Diseases
  • Cardiology
  • Epidemiology

Background:

  • Cardiovascular disease (CVD) is a leading cause of morbidity and mortality in individuals with HIV.
  • Hepatitis C virus (HCV) infection is common among HIV-infected individuals and may influence CVD risk.

Purpose of the Study:

  • To investigate the association between hepatitis C co-infection and the prevalence of cardiovascular disease (CVD) in a cohort of HIV-infected individuals.

Main Methods:

  • Cross-sectional analysis of data from the HIV-Longitudinal Interrelationships of Viruses and Ethanol (HIV-LIVE) cohort.
  • Logistic regression was used to compare CVD prevalence between HIV-infected individuals with and without hepatitis C co-infection.

Main Results:

  • The prevalence of CVD was substantially higher in individuals co-infected with HIV and hepatitis C (11.1%) compared to those with HIV alone (2.5%).
  • Hepatitis C co-infection was associated with significantly higher age-adjusted odds of CVD (adjusted OR 4.65).
  • This association remained robust after adjusting for various sociodemographic, substance use, and cardiovascular risk factors.

Conclusions:

  • Hepatitis C co-infection is linked to increased odds of prevalent CVD among HIV-infected individuals.
  • These findings suggest that hepatitis C may contribute to an elevated risk of cardiovascular disease in the context of HIV infection.
Abstract

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