Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Melatonin and anesthesia: a clinical perspective.

Mohamed Naguib1, Vijaya Gottumukkala, Peter A Goldstein

  • 1Department of Anesthesiology and Pain Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA. Naguib@mdanderson.org

Journal of Pineal Research
|January 3, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Fentanyl Is Not a WMD.

Journal of general internal medicine·2026
Same author

The Myth of Depth of Anesthesia Monitors: When a "Normal" Bispectral Index Does not Mean What You Think It Means.

Anesthesia and analgesia·2026
Same author

Are "GABAergic" Agents Really So Selective for GABA? Implications for Single- versus Multi-Site Hypotheses From Promiscuous Behavior of Anesthetics and Their Molecular Targets In Vitro.

Anesthesia and analgesia·2026
Same author

Care of the immunocompromised cancer patient in the perioperative period: Narrative review.

Indian journal of anaesthesia·2025
Same author

Electroencephalographic Changes During General Anesthesia in Patients With a History of Chemotherapy.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2025
Same author

From Data to Decisions: Harnessing Multi-Agent Systems for Safer, Smarter, and More Personalized Perioperative Care.

Journal of personalized medicine·2025

Melatonin exhibits hypnotic, pain-relieving, and seizure-preventing effects, making it a potential anesthetic. It offers sedation and anxiety reduction without impairing cognitive function, unlike midazolam.

Area of Science:

  • Neuroscience
  • Anesthesiology
  • Pharmacology

Background:

  • Melatonin possesses hypnotic, antinociceptive, and anticonvulsant properties.
  • It is recognized as a potential novel hypnotic-anesthetic agent.

Purpose of the Study:

  • To evaluate melatonin's efficacy and safety as a premedicant compared to midazolam.
  • To investigate the anesthetic properties of melatonin and its analogs in rats.
  • To explore the underlying mechanisms of melatonin's anesthetic effects, particularly its interaction with the GABAergic system.

Main Methods:

  • Clinical studies assessing melatonin as a premedicant in adults and children.
  • Animal studies using melatonin and its analogs (2-bromomelatonin, phenylmelatonin) to assess anesthetic properties.

Related Experiment Videos

  • In vitro and in vivo experiments to investigate the role of the GABAergic system in melatonin's effects.

    • Main Results:

    • Melatonin is an effective premedicant, inducing sedation and anxiolysis without psychomotor impairment or affecting recovery quality.
    • Melatonin premedication reduced the required doses of propofol and thiopental.
    • Melatonin and its analogs demonstrated anesthetic and potent antinociceptive effects in rats.
    • Melatonin administration increased central nervous system GABA concentrations and modulated GABAergic transmission.
    • Melatonin's central anesthetic effects are partly mediated by GABAergic system activation.

    Conclusions:

    • Melatonin is a promising premedicant with advantages over midazolam regarding cognitive function and recovery.
    • Melatonin exhibits anesthetic properties, potentially acting via the GABAergic system.
    • Further research is needed to fully elucidate melatonin's general anesthetic properties at multiple biological levels.