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The Application of 1% Methylene Blue Dye As a Single Technique in Breast Cancer Sentinel Node Biopsy
Published on: June 1, 2019
[Subareolar injection for sentinel lymph node biopsy in multiple breast cancer]
G D'Eredità1, V L Troilo, C Giardina
1Università degli Studi di Bari, Dipartimento di Scienze Chirurgiche Generali e Specialistiche.
Il Giornale Di Chirurgia
|January 3, 2007
Summary
Sentinel lymph node biopsy (SNLB) using subareolar injection is accurate for multifocal breast cancer (MC). This technique shows high identification rates and low false negative rates, making it reliable for MC patients.
Area of Science:
- Oncology
- Surgical Pathology
- Radiopharmaceuticals
Background:
- Multifocal breast cancer (MC) presents unique challenges for accurate staging.
- Sentinel lymph node biopsy (SNLB) is standard for staging breast cancer.
- The reliability of SLNB in MC patients requires further investigation.
Purpose of the Study:
- To evaluate the feasibility and accuracy of axillary lymphatic mapping and SLNB using subdermal injection of 99mTc-labeled albumin and subareolar (SA) blue dye injection in patients with multifocal breast cancer (MC).
- To compare the outcomes in MC patients with those having unifocal breast cancer.
Main Methods:
- Retrospective analysis of 250 patients undergoing axillary lymph node mapping and SLNB from January 1999 to March 2006.
- Subdermal injection of 99mTc-labeled albumin combined with SA injection of blue dye for lymphatic mapping.
- Comparison of results between 32 patients with MC and 218 patients with unifocal breast cancer.
Main Results:
- Metastatic lymph node involvement was significantly higher in the MC group (p=.001).
- The false negative (FN) rate was 5.8% in MC patients versus 9.6% in unifocal cancer patients.
- Overall accuracy was 96.8% for MC and 97.6% for unifocal cancers; sensitivity was 94.4% for MC and 91.2% for unifocal cancers.
Conclusions:
- Axillary lymphatic mapping and SLNB using the SA injection technique are reliable and accurate in patients with multifocal breast cancer (MC).
- The technique demonstrates a high sentinel lymph node identification rate and a low false negative rate.
- This method is recommended for SLNB in patients diagnosed with MC of the breast.
