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Substance P and the inflammatory and immune response
1Molecular Neurobiology Lab, Veterans Administration Medical Center, Minneapolis, Minnesota 55417.
Annals of the New York Academy of Sciences
|January 1, 1991
Summary
Substance P (SP) may promote inflammation in both the central nervous system and peripheral tissues following injury. Understanding SP
Area of Science:
- Neuroscience
- Immunology
- Cell Biology
Background:
- Substance P (SP) is a neuropeptide implicated in inflammatory processes.
- SP's role in central nervous system (CNS) and peripheral tissue inflammation after injury is under investigation.
- The source of SP in the CNS differs from peripheral tissues, presenting a unique research question.
Purpose of the Study:
- To investigate the proinflammatory actions of SP in both CNS and peripheral tissues post-injury.
- To explore the potential origin of SP in the CNS, possibly from circulating leukocytes.
- To understand SP's role in the inflammatory cascade, nociceptor sensitization, and immune cell recruitment.
Main Methods:
- The study suggests investigating the cascade of events post-tissue injury.
- Focus on factors leading to nociceptor sensitization and SP release.
- Examine regulation of SP receptor expression and its implications.
Main Results:
- Findings suggest SP has proinflammatory actions in both peripheral tissues and the CNS after injury.
- Leukocytes are identified as a potential source of SP in the CNS.
- SP receptor expression may direct leukocyte infiltration and influence astrocyte reactivity.
Conclusions:
- SP likely plays a significant role in coordinating inflammatory and immune responses to tissue injury.
- Further research is needed to elucidate SP's precise role in the injury cascade.
- Advances in tachykinin receptor cloning and SP receptor antagonists facilitate future investigations.