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Thyroid function, endothelium, and inflammation in hemodialyzed patients: possible relations?
Jolanta Malyszko1, Jacek S Malyszko, Krystyna Pawlak
1Department of Nephrology and Transplantology, Medical University, Bialystok, Poland. jolmal@poczta.onet.pl
Summary
Thyroid hormones are altered in hemodialysis patients, linked to inflammation and endothelial dysfunction. These findings suggest thyroid axis dysfunction is associated with kidney disease complications.
Area of Science:
- Nephrology
- Endocrinology
- Cardiovascular Research
Background:
- Renal function significantly impacts thyroid gland activity.
- Kidney diseases commonly involve hemostasis disturbances and inflammation.
- Endothelial dysfunction may serve as a link between hemostasis and inflammation in renal disease.
Purpose of the Study:
- To investigate the relationship between thyroid hormones and markers of endothelial damage and inflammation in hemodialysis patients.
- To compare these markers between hemodialysis patients and healthy volunteers.
Main Methods:
- A cross-sectional study involving 96 hemodialysis (HD) patients and 39 healthy controls.
- Measurement of thyroid hormones (free T3, total T3).
- Assessment of endothelial damage markers (von Willebrand factor, thrombomodulin, ICAM, CD146), inflammation markers (hs-CRP, TNF-alpha), and hemostatic parameters using commercial kits.
Main Results:
- Hemodialysis patients exhibited lower free T3 and total T3 levels compared to controls.
- Markers of endothelial dysfunction and inflammation were significantly elevated in HD patients.
- Thyroid hormone levels in HD patients were independently associated with dialysis duration, albumin, iron, ferritin, CRP, and F1+2, with varying correlations based on CRP levels.
Conclusions:
- Novel associations between thyroid hormones and markers of endothelial dysfunction and inflammation in hemodialysis patients were identified.
- Thyroid dysfunction in uremia is linked to dialysis duration, endothelial damage, and inflammation.
- Further research is warranted to explore the thyroid axis and endothelium relationship in hemodialysis subjects.
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