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Hypertension and its management: a problem in need of new treatment strategies

J M Neutel1

  • 1Veterans Affairs Medical Center, Long Beach, Calfornia, USA. JMNeutel@aol.com

Journal of the Renin-Angiotensin-Aldosterone System : JRAAS
|January 3, 2007
PubMed

Insights

Hypertension treatments effectively reduce stroke but not heart disease. Angiotensin II receptor blockers (ARBs) like valsartan offer cardiovascular benefits beyond blood pressure control.

Area of Science:

  • Cardiology
  • Nephrology
  • Pharmacology

Background:

  • Hypertension management has improved cerebrovascular disease outcomes but shows limited success in reducing coronary artery disease.
  • Hypertension is a complex inherited condition associated with multiple cardiovascular risk factors contributing to heart disease development.

Purpose of the Study:

  • To evaluate Angiotensin II receptor blockers (ARBs) as a treatment strategy for coronary artery disease in hypertensive patients.
  • To highlight the benefits of selective ARBs, such as valsartan, in managing multifaceted cardiovascular risks.

Main Methods:

  • The study focuses on the therapeutic role of selective Angiotensin II receptor blockers (ARBs).
  • Valsartan is presented as a specific example of an ARB with high selectivity.

Main Results:

  • Angiotensin II receptor blockers (ARBs) offer a promising alternative for addressing coronary artery disease.
  • Valsartan demonstrates well-tolerated, once-daily dosing, improving patient compliance.
  • These agents provide cardiovascular benefits beyond blood pressure reduction, including renoprotection and mitigation of cardiovascular growth.

Conclusions:

  • Selective Angiotensin II receptor blockers (ARBs), exemplified by valsartan, present a valuable therapeutic option for hypertension.
  • These drugs offer comprehensive cardiovascular protection, addressing multiple risk factors associated with heart disease.
  • The favorable tolerability and dosing regimen of ARBs enhance their clinical utility in managing hypertensive patients with coronary artery disease.

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