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Inhibitory binding of adenosine diphosphoribosyl transferase to the DNA primer site of reverse transcriptase
1Laboratory for Environmental Toxicology and Chemistry, San Francisco State University, Tiburon, CA 94920.
Biochemical and Biophysical Research Communications
|October 31, 1991
Abstract:
Purified adenosine diphosphoribose transferase protein binds to RNA-DNA hybrid templates of reverse transcriptase at the DNA primer site and inhibits RT activity of HIV and MMu RTs. This action is prevented by auto-poly-ADP-ribosylation of the transferase but is reinduced by inhibitory ligands of the enzyme.