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Updated: Jul 17, 2026
06:18
An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause
Published on: August 13, 2019
Estrogens and aspects of prostate disease
Domenico Prezioso1, Louis J Denis, Helmut Klocker
1Oncology Center, Antwerpen, Belgium.
Summary
Estrogens play a dual role in prostate cancer, potentially suppressing or promoting it. Dietary estrogens may offer cancer-repressive benefits, warranting further investigation into their mechanisms.
Area of Science:
- Endocrinology
- Oncology
- Molecular Biology
Background:
- Estrogens are implicated in prostate carcinogenesis, with roles in both cancer suppression and promotion.
- The interplay between estrogens and androgens influences prostate gland growth.
- Emerging research clarifies the complex molecular mechanisms of estrogen action in the prostate.
Purpose of the Study:
- To review the multifaceted role of estrogens in prostate cancer pathogenesis.
- To explore the potential cancer-suppressive effects of dietary estrogens.
Main Methods:
- Literature review of existing research on estrogens and prostate cancer.
- Analysis of molecular events regulating prostate growth.
- Examination of epidemiological and experimental data on dietary estrogens.
Main Results:
- Estrogens exhibit a complex, concentration-dependent effect on prostate carcinogenesis.
- Synergistic action of low-dose estrogens and androgens can promote aberrant prostate growth.
- Dietary estrogens show potential for cancer-repressive effects in the prostate.
Conclusions:
- Estrogen's role in prostate cancer is context-dependent, involving both suppressive and promotional activities.
- Understanding these roles is crucial for developing targeted therapies and preventive strategies.
- Dietary estrogens represent a promising avenue for prostate cancer prevention.
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