Related Experiment Video
Updated: Jul 17, 2026

07:12
Chronic Post-Ischemia Pain Model for Complex Regional Pain Syndrome Type-I in Rats
Published on: January 21, 2020
Complex regional pain syndrome complicating total knee arthroplasty.
A W R Burns1, D A Parker, M R J Coolican
1Sydney Orthopaedic Arthritis and Sports Medicine, Chatswood, New South Wales, Australia.
Journal of Orthopaedic Surgery (Hong Kong)
|January 4, 2007
Summary
Early management of complex regional pain syndrome-type 1 (CRPS-1) after total knee arthroplasty (TKA) leads to outcomes similar to uncomplicated TKA. This study compared CRPS-1 TKA patients with controls, finding significant improvement over preoperative states.
Area of Science:
- Orthopedic surgery
- Pain management
- Rehabilitation medicine
Background:
- Complex regional pain syndrome-type 1 (CRPS-1) can complicate total knee arthroplasty (TKA).
- Understanding the long-term outcomes of CRPS-1 post-TKA is crucial for patient management.
Purpose of the Study:
- To compare long-term outcomes of TKA patients with CRPS-1 to those with uncomplicated TKA and preoperative osteoarthritis.
- To evaluate functional recovery and pain scores in CRPS-1 patients following TKA.
Main Methods:
- Retrospective review of 1280 TKA patients; 8 diagnosed with CRPS-1 post-operatively.
- Exclusion of patients with inflammatory arthritis, component issues, or infection.
- Comparison of CRPS-1 patients with age- and sex-matched controls (uncomplicated TKA and pre-operative osteoarthritis knees).
- Assessment of range of motion, WOMOIAI, SF-36, and Knee Society scores over a mean 54-month follow-up.
Main Results:
- CRPS-1 patients achieved similar SF-36, WOMOIAI, and Knee Society scores compared to uncomplicated TKA patients after treatment.
- CRPS-1 patients showed significant improvement compared to their preoperative osteoarthritic state.
- The incidence of CRPS-1 following TKA was 0.7%.
Conclusions:
- Early intervention and management of CRPS-1 after TKA result in comparable long-term functional outcomes to uncomplicated TKA.
- CRPS-1 post-TKA, when appropriately treated, does not necessarily lead to a poorer long-term prognosis than standard TKA recovery.
