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Updated: Jul 17, 2026

Synthesis of Graphene-Hydroxyapatite Nanocomposites for Potential Use in Bone Tissue Engineering
Published on: July 27, 2022
Biocompatability of hydroxyapatite composite as a local drug delivery system
A Krisanapiboon1, B Buranapanitkit, K Oungbho
1Department of Orthopaedic and Physical Medicine, Faculty of Medicine, Prince of Songkla University, Haadyai, Songkhla, Thailand.
Purpose:
To investigate the biocompatibility of hydroxyapatite composite (hydroxyapatite, plaster of Paris, and chitosan) impregnated with gentamicin, fosfomycin, imipenem, or amphotericin B.
Methods:
The interactions of the extract from each drug against osteoblast were tested using the methylthiotetrazole test.
Results:
Extracts from all drugs showed good biocompatibility at concentrations varying from 10 microgram/ml to 1000 microgram/ml. Imipenem and amphotericin B at a concentration of 1000 microgram/ml had a significantly higher percentage of cell viability than the control group. No morphological change of osteoblast was observed in all drug tests at any concentrations.
Conclusion:
The hydroxyapatite composite had a good biocompatibility for carrying gentamicin, fosfomycin, imipenem, or amphotericin B.
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