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Related Concept Videos

Cell Adhesion Molecules - Types and Functions01:20

Cell Adhesion Molecules - Types and Functions

Cell adhesion molecules (CAMs) are pivotal to multicellularity and the coordinated functioning of tissues and organ systems. They enable physical interactions between cells and provide mechanical strength to tissues. They also function as receptors for signal transmission across the plasma membrane. The CAMs are broadly classified into four families - integrins, cadherins, selectins, and immunoglobulin-like CAMs (IgCAMs).
CAM Families
The Integrin family of proteins is primarily  involved in a...
Cell Adhesion Molecules - Types and Functions01:20

Cell Adhesion Molecules - Types and Functions

Cell adhesion molecules (CAMs) are pivotal to multicellularity and the coordinated functioning of tissues and organ systems. They enable physical interactions between cells and provide mechanical strength to tissues. They also function as receptors for signal transmission across the plasma membrane. The CAMs are broadly classified into four families - integrins, cadherins, selectins, and immunoglobulin-like CAMs (IgCAMs).
CAM Families
The Integrin family of proteins is primarily  involved in a...
Overview of Cell-Matrix Interactions01:24

Overview of Cell-Matrix Interactions

The extracellular matrix or ECM holds cells together to form a tissue and allows the cells within the tissue to communicate. ECM comprises proteins such as fibronectin, collagen, laminin, etc. The most abundant protein in this space is collagen. Collagen fibers are interwoven with carbohydrate-containing protein molecules called proteoglycans. ECM allows cell migration and provides a structural scaffold at cell adhesion that anchors the cell when the extracellular matrix proteins interact with...
Glycocalyx and its Functions01:14

Glycocalyx and its Functions

The glycocalyx is a carbohydrate-rich, fuzzy-appearing layer on the outer surface of the cell membrane. It is highly hydrophilic, because of this it attracts large amounts of water to the cell's surface. This aids the cell's interaction with the watery environment and also helps it to obtain substances dissolved in the water. It is also important for cell identification, self/non-self determination, and embryonic development and is used in cell-to-cell attachments to form tissues.
Components of...
Adhesion01:14

Adhesion

Adhesion occurs when one type of molecule is attracted to a different molecule. Water exhibits adhesive properties in the presence of polar surfaces, such as glass or cellulose in plants. For instance, when water is poured into a glass, the positively charged hydrogen molecules of water are more attracted to the negatively charged oxygen molecules in the silica than to the oxygen in neighboring water molecules.
Capillary action is a result of water’s adhesive tendencies. When a narrow glass...
Immunoglobulin-like Cell Adhesion Molecules01:31

Immunoglobulin-like Cell Adhesion Molecules

Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...

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Related Experiment Video

Updated: Jul 17, 2026

Thin Film Composite Silicon Elastomers for Cell Culture and Skin Applications: Manufacturing and Characterization
08:02

Thin Film Composite Silicon Elastomers for Cell Culture and Skin Applications: Manufacturing and Characterization

Published on: July 3, 2018

Cell/surface interactions and adhesion on bioactive glass 45S5.

S Levy1, M Van Dalen, S Agonafer

  • 1Princeton Institute of Science and Technology of Materials (PRISM) and The Department of Mechanical and Aerospace Engineering, Princeton University, Princeton, NJ 08544, USA.

Journal of Materials Science. Materials in Medicine
|January 4, 2007
PubMed
Summary

Surface texture significantly impacts how cells interact with bioactive glass. Rougher textures promote better cell spreading and influence elemental distribution, suggesting improved medical applications for textured bioactive glasses.

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Control of Cell Adhesion using Hydrogel Patterning Techniques for Applications in Traction Force Microscopy
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Last Updated: Jul 17, 2026

Thin Film Composite Silicon Elastomers for Cell Culture and Skin Applications: Manufacturing and Characterization
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Thin Film Composite Silicon Elastomers for Cell Culture and Skin Applications: Manufacturing and Characterization

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Control of Cell Adhesion using Hydrogel Patterning Techniques for Applications in Traction Force Microscopy
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Control of Cell Adhesion using Hydrogel Patterning Techniques for Applications in Traction Force Microscopy

Published on: January 29, 2022

Area of Science:

  • Biomaterials Science
  • Cell Biology
  • Surface Chemistry

Background:

  • Bioactive glasses, such as 45S5, are crucial biomaterials for bone regeneration.
  • Understanding cell-surface interactions is key to optimizing their clinical performance.
  • Surface properties, including texture, can profoundly influence biological responses.

Purpose of the Study:

  • To investigate the influence of surface texture (smooth vs. rough) on 45S5 bioactive glass.
  • To analyze cell spreading and its relationship with surface topography.
  • To determine the elemental composition of different surface textures.

Main Methods:

  • Cell culture experiments were performed on smooth and rough 45S5 bioactive glass surfaces.
  • Cell spreading was quantified to assess cell-surface interactions.
  • Energy dispersive X-ray spectroscopy (EDS) was employed to map elemental distribution (Ca, P, Na, O).

Main Results:

  • Rough bioactive glass surfaces demonstrated enhanced cell spreading compared to smooth surfaces.
  • EDS analysis revealed differences in the distribution of calcium, phosphorous, sodium, and oxygen based on surface texture.
  • Cell adhesion and proliferation were observed to be texture-dependent.

Conclusions:

  • Surface texture is a critical factor modulating cell behavior on bioactive glasses.
  • Textured bioactive glasses offer potential for improved integration and efficacy in medical applications.
  • Tailoring surface topography can optimize the biological response for regenerative medicine.