Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Ageing and the brain.

M M Esiri1

  • 1Department of Clinical Neurology, University of Oxford, and Department of Neuropathology, Oxford Radcliffe NHS Trust, Oxford, UK.

The Journal of Pathology
|January 4, 2007
PubMed
Summary
This summary is machine-generated.

Brain aging involves modest neuron loss and reduced neuron size, impacting connections. Oxidative stress, glycation, and calcium issues contribute, influenced by genes and environment.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Neuropathological Evidence of Reduced Amyloid Beta and Neurofibrillary Tangles in Multiple Sclerosis Cortex.

Annals of neurology·2025
Same author

Neuropathology of the hippocampus in FTLD-Tau with Pick bodies: a study of the BrainNet Europe Consortium.

Neuropathology and applied neurobiology·2012
Same author

Neuropathologic evidence of endothelial changes in cerebral small vessel disease.

Neurology·2011
Same author

Focal and diffuse cortical degenerative changes in a marmoset model of multiple sclerosis.

Multiple sclerosis (Houndmills, Basingstoke, England)·2010
Same author

MS: is it one disease?

International MS journal·2009
Same author

Loss of [3H]4-DAMP binding to muscarinic receptors in the orbitofrontal cortex of Alzheimer's disease patients with psychosis.

Psychopharmacology·2008
Same journal

Tumor Invasive Border Index (TIBI) in colorectal cancer: linking infiltrative morphology to molecular insights.

The Journal of pathology·2026
Same journal

Lipodystrophy and adipose tissue recovery are mediated by the Wnt/lipogenesis axis during skin fibrosis.

The Journal of pathology·2026
Same journal

Optical mapping reveals a higher level of large-scale structural variants in a family with paternally transmitted myotonic dystrophy and independent Parkinson's disease.

The Journal of pathology·2026
Same journal

FTO-mediated m6A modification of protein disulfide-isomerase activates VEGFA-VEGFR2 to suppress programmed cell death in osteosarcoma.

The Journal of pathology·2026
Same journal

Dopamine inhibits retinal pathological neovascularization in the oxygen-induced retinopathy mouse model.

The Journal of pathology·2026
Same journal

Aberrant alternative splicing of purinergic receptor P2RX4 prevents sensitivity towards combinatorial treatment in colorectal and pancreatic cancer.

The Journal of pathology·2026
See all related articles

Area of Science:

  • Neuroscience
  • Gerontology
  • Human Physiology

Background:

  • Brain aging is a complex process with significant macroscopic and microscopic changes.
  • Previous research suggested more substantial neuron loss than currently understood.

Purpose of the Study:

  • To review current evidence on human brain changes during aging.
  • To explore the underlying causes and contributing factors of these age-related brain alterations.

Main Methods:

  • Comprehensive literature review of studies on brain aging.
  • Analysis of macroscopic and microscopic brain changes.
  • Discussion of cellular mechanisms and etiological factors.

Main Results:

  • Neuron loss in aging is more modest and specific to certain populations.

Related Experiment Videos

  • Remaining neurons exhibit reduced size, affecting dendritic and axonal arborizations.
  • Key contributing factors include oxidative metabolism, glycation, and calcium dysregulation.

    • Conclusions:

    • Brain aging involves nuanced neuronal changes rather than widespread loss.
    • Genetic and environmental factors play crucial roles in modulating aging processes and responses.