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A fluorous, Pummerer cyclative-capture strategy for the synthesis of N-heterocycles
Laura A McAllister1, Rosemary A McCormick, Karen M James
1Department of Chemistry, The Joseph Black Building, The University of Glasgow, Glasgow G12 8QQ, Scotland.
Abstract:
A fluorous, cyclative-capture strategy based on a new Pummerer cyclization process allows rapid access to tagged, heterocyclic frameworks. Convenient modification of the fluorous, heterocyclic scaffolds by using a variety of approaches including Pd-catalyzed cross-couplings is possible. Traceless, reductive cleavage of the fluorous-phase tag or oxidative cleavage and further elaboration, completes a strategy for the high-throughput, fluorous-phase synthesis of a diverse range of N-heterocycles.
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