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The Nijmegen Hemostasis Assay: Simultaneous Fluorogenic Measurement of Thrombin and Plasmin Generation in a Single Well
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Delayed thrombin generation is not associated with fibrinopeptide formation during prolonged cardiopulmonary bypass

D Belway1, F D Rubens, B Henley

  • 1Department of Cardiovascular Perfusion, University of Ottawa Heart Institute, Ottawa, Ontario, Canada.

Perfusion
|January 5, 2007
PubMed

Patients with heparin-induced thrombocytopenia urgently requiring surgery with cardiopulmonary bypass (CPB) present a unique management challenge that must be addressed by the use of alternative anticoagulants. Although clinical success with the direct thrombin inhibitor hirudin has been reported, there is sparse information in the literature supporting the efficacy of this drug as an anti-thrombotic to prevent fibrin formation during CPB. In this report, we describe the efficacy of this drug to prevent thrombin-mediated fibrin formation during CPB.

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