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Updated: Jul 17, 2026

Detection of Aggregation-Prone Behavior in Mutant P53 V157F Breast Cancer Cells Using Multipoint Thioflavin T Fluorescence
Published on: December 30, 2025
Decreased expression of tumor protein p53-induced nuclear protein 1 (TP53INP1) in breast carcinoma
Yasuhiro Ito1, Yoshiharu Motoo, Hiroshi Yoshida
1Department of Surgery, Kuma Hospital, 8-2-35, Shimoyamate-Dori, Chuo-ku, Kobe City, 650-0011, Japan. ito01@kuma-h.or.jp
Background:
Tumor protein p53-induced nuclear protein 1 (TP53INP1) is a stress-induced protein and plays a role in cell cycle arrest and p53-mediated apoptosis. In this study, TP53INP1 expression in human breast carcinoma was investigated.
Materials And Methods:
TP53INP1 and aberrant p53 expression were investigated immunohistochemically in 81 cases of breast carcinoma.
Results:
Diffuse and intense TP53INP1 expression was observed in the normal mammary gland. Decreased TP53INP1 expression was found in 45 cases (55.6%) of breast carcinoma. The TP53INP1 expression level was inversely linked to tumor size, positive lymph node metastasis, high histological grade and aberrant p53 expression.
Conclusion:
Decreased expression of TP53INP1 is involved in breast carcinoma progression.
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