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Related Experiment Video

Updated: Jul 17, 2026

Simultaneous Quantification of Anti-vector and Anti-transgene-Specific CD8+ T Cells Via MHC I Tetramer Staining After Vaccination with a Viral Vector

Simultaneous Quantification of Anti-vector and Anti-transgene-Specific CD8⁺ T Cells Via MHC I Tetramer Staining After Vaccination with a Viral Vector

Published on: November 28, 2018

Exploiting 4-1BB costimulation for enhancing antiviral vaccination.

Jodie M Harrison¹, Edward M Bertram, Ian A Ramshaw

¹Department of Immunology and Genetics, John Curtin School of Medical Research, Australian National University, Canberra, Australia.

Viral Immunology

|January 5, 2007

Summary

4-1BB (tumor necrosis factor receptor superfamily member) costimulation enhances CD8(+) T cell responses. This review explores its role in antiviral immunity and potential use in boosting antiviral vaccines.

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Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant

Published on: May 27, 2011

Area of Science:

Immunology
Virology
Vaccinology

Background:

4-1BB (tumor necrosis factor receptor superfamily member) is a key costimulatory molecule.
It significantly regulates CD8(+) T cell responses, particularly in tumor models.
Emerging evidence highlights its crucial role in antiviral CD8(+) T cell immunity.

Purpose of the Study:

To review the role of 4-1BB in antiviral CD8(+) T cell responses.
To explore the exploitation of 4-1BB for enhancing antiviral vaccine efficacy.

Main Methods:

Literature review of studies on 4-1BB in T cell regulation.
Analysis of 4-1BB's function in antiviral immunity.
Examination of strategies for leveraging 4-1BB in vaccine development.

Main Results:

4-1BB costimulation effectively boosts CD8(+) T cell activity.
Its function extends beyond tumor immunity to antiviral responses.
Agonistic anti-4-1BB antibodies show promise in preclinical models.

Conclusions:

4-1BB is a critical regulator of antiviral CD8(+) T cell immunity.
Targeting 4-1BB represents a promising strategy for improving antiviral vaccine effectiveness.