Exploiting 4-1BB costimulation for enhancing antiviral vaccination
Jodie M Harrison1, Edward M Bertram, Ian A Ramshaw
1Department of Immunology and Genetics, John Curtin School of Medical Research, Australian National University, Canberra, Australia.
Abstract:
4-1BB, a member of the tumor necrosis factor receptor (TNFR) superfamily, is emerging as an important costimulatory molecule, particularly in the regulation of CD8(+) T cell responses. Costimulation through 4-1BB, such as by utilizing agonistic anti-4-1BB monoclonal antibodies, has been well studied in various tumor models. However, 4-1BB is also an important regulator of antiviral CD8(+) T cell responses. This review summarizes these findings and describes how 4-1BB is beginning to be exploited in terms of boosting antiviral vaccine responses.
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