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Published on: November 14, 2025
Status epilepticus after stroke is associated with increased long-term case fatality
Susanne Knake1, Justine Rochon, Sarah Fleischer
1Department of Neurology, Interdisciplinary Epilepsy Center, University Hospital Giessen and Marburg, Marburg, Germany.
Epilepsia
|January 5, 2007
Summary
Patients experiencing status epilepticus (SE) from stroke face double the mortality risk compared to acute stroke patients without SE. This highlights the critical need for focused care in stroke-related SE cases.
Area of Science:
- Neurology
- Epidemiology
- Critical Care Medicine
Background:
- Status epilepticus (SE) is a neurological emergency.
- Cerebrovascular events are a common cause of SE.
- Long-term outcomes for SE patients with cerebrovascular etiology require further investigation.
Purpose of the Study:
- To compare the long-term case fatality of patients with a first episode of status epilepticus (SE) of cerebrovascular etiology versus acute stroke patients without SE.
- To assess the impact of SE on survival in patients with cerebrovascular disease.
Main Methods:
- Retrospective comparison of patients from a prospective SE study and a local stroke registry.
- Kaplan-Meier survival analysis and log-rank tests were used.
- An extended Cox model analyzed the risk of death, adjusting for confounders like age, sex, stroke type, and lesion location.
Main Results:
- The study included 166 patients (93 SE group, 73 AS group).
- Univariate analysis showed no significant difference in survival between groups (p=0.0832).
- Multivariable analysis revealed that SE patients had approximately double the risk of death after 6 months (HR 2.12, p=0.0392).
Conclusions:
- Status epilepticus in cerebrovascular disease patients signifies a high risk of mortality within 3 years.
- The case fatality risk associated with recurrent SE or seizures is comparatively lower.
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