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GenBank.

Dennis A Benson1, Ilene Karsch-Mizrachi, David J Lipman

  • 1National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Building 38A, 8600 Rockville Pike, Bethesda, MD 20894, USA.

Nucleic Acids Research
|January 5, 2007
PubMed
Summary
This summary is machine-generated.

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GenBank is a vital nucleotide sequence database featuring over 240,000 organisms. It offers integrated data access and analysis tools for researchers worldwide.

Area of Science:

  • Bioinformatics
  • Genomics
  • Molecular Biology

Background:

  • GenBank is a primary repository for publicly available nucleotide sequences.
  • It encompasses data from over 240,000 named organisms.
  • Submissions originate from individual laboratories and large-scale sequencing initiatives.

Purpose of the Study:

  • To describe the scope and accessibility of the GenBank database.
  • To highlight the integrated data retrieval and analysis services offered by NCBI.
  • To inform users about data submission and access methods.

Main Methods:

  • Data collection through laboratory and large-scale project submissions.
  • Utilizing web-based (BankIt) and standalone (Sequin) submission programs.
  • Daily data exchange with international nucleotide sequence databases (EMBL, DDBJ).

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Main Results:

  • GenBank contains nucleotide sequences from over 240,000 organisms.
  • Integrated access is provided via NCBI's Entrez system.
  • Tools like BLAST enable sequence similarity searches.

Conclusions:

  • GenBank serves as a comprehensive, globally accessible resource for nucleotide sequences.
  • NCBI's integrated platform enhances data discovery and analysis.
  • FTP access is available for database releases and updates.