Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Expression profiling in granulomatous lung disease.

Edward S Chen1, David R Moller

  • 1Division of Pulmonary and Critical Care Medicine, Department of Medicine, The Johns Hopkins University, Baltimore, Maryland, USA.

Proceedings of the American Thoracic Society
|January 5, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bridging the Divide: Divergent Diagnostic Philosophies and Practice Pathways for Cardiac Sarcoidosis between Japan and North America.

Journal of cardiac failure·2026
Same author

Management of Clinical Cardiac Sarcoidosis Isolated to the Heart With Tumor Necrosis Factor-Alpha Inhibitors.

JACC. Case reports·2025
Same author

TEAM Sarcoidosis: Creating a Multidisciplinary Care Team for Complex Clinical Management.

Chest·2025
Same author

Delays in Referral to Multidisciplinary Care for Black Individuals With Sarcoidosis.

CHEST pulmonary·2025
Same author

The Impact of the Unknown: Patient Experiences With Uncertainty in Sarcoidosis.

Chest·2025
Same author

Working Together in Sarcoidosis: Experience and Impact of a Formalized Multidisciplinary Discussion.

Annals of the American Thoracic Society·2025
Same journal

Note from the editor.

Proceedings of the American Thoracic Society·2012
Same journal

Adaptation, evaluation, and updating of guidelines: article 14 in Integrating and coordinating efforts in COPD guideline development. An official ATS/ERS workshop report.

Proceedings of the American Thoracic Society·2012
Same journal

Disseminating and implementing guidelines: article 13 in Integrating and coordinating efforts in COPD guideline development. An official ATS/ERS workshop report.

Proceedings of the American Thoracic Society·2012
Same journal

Reporting and publishing guidelines: article 12 in Integrating and coordinating efforts in COPD guideline development. An official ATS/ERS workshop report.

Proceedings of the American Thoracic Society·2012
Same journal

Moving from evidence to developing recommendations in guidelines: article 11 in Integrating and coordinating efforts in COPD guideline development. An official ATS/ERS workshop report.

Proceedings of the American Thoracic Society·2012
Same journal

How to integrate multiple comorbidities in guideline development: article 10 in Integrating and coordinating efforts in COPD guideline development. An official ATS/ERS workshop report.

Proceedings of the American Thoracic Society·2012
See all related articles

Genomic and proteomic technologies offer new insights into granulomatous lung diseases like sarcoidosis. These "-omics" approaches can improve diagnosis, prediction, and treatment for these complex conditions.

Area of Science:

  • Pulmonary Medicine
  • Genomics
  • Proteomics

Background:

  • Granulomatous lung diseases (e.g., sarcoidosis, tuberculosis) cause significant global morbidity and mortality.
  • Disease susceptibility, clinical course, and pathogenic mechanisms remain poorly understood.
  • Heterogeneous clinical manifestations complicate diagnosis and treatment.

Purpose of the Study:

  • To explore the application of genomic and proteomic technologies in understanding granulomatous lung diseases.
  • To identify gene/protein expression patterns associated with clinical disease.
  • To uncover novel pathways involved in disease pathogenesis.

Main Methods:

  • Utilized genomic and proteomic technologies to analyze gene and protein expression.
  • Investigated patterns correlating with clinical disease characteristics.

Related Experiment Videos

  • Focused on diseases including sarcoidosis, hypersensitivity pneumonitis, Wegener's granulomatosis, chronic beryllium disease, and tuberculosis.

    • Main Results:

    • '-Omics' approaches show potential for novel insights into disease pathogenesis.
    • Identified patterns that may track with clinical disease presentation.
    • Highlighted the complexity of granulomatous lung disease mechanisms.

    Conclusions:

    • Genomic and proteomic studies offer promising tools for advancing the understanding of granulomatous lung diseases.
    • These approaches can potentially improve diagnostic accuracy, clinical classification, and therapeutic strategies.
    • Multidisciplinary collaboration is crucial for realizing the full potential of these technologies in managing complex lung diseases.