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Related Experiment Videos

A costimulatory function for T cell CD40.

Melissa E Munroe1, Gail A Bishop

  • 1Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA.

Journal of Immunology (Baltimore, Md. : 1950)
|January 5, 2007
PubMed
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CD40 on T cells acts as a costimulatory molecule, enhancing T cell activation and potentially amplifying autoimmune responses. This finding reveals new functions for T cell CD40 in inflammation and autoimmunity.

Area of Science:

  • Immunology
  • Autoimmunity Research
  • Cellular Biology

Background:

  • CD40 is implicated in inflammation and autoimmunity.
  • B cell CD40 activation can lead to autoantibody production.
  • T cells, particularly CD4(+) T lymphocytes in autoimmune conditions, express increased CD40.

Purpose of the Study:

  • To investigate the functional role of CD40 on T lymphocytes.
  • To test if CD40 acts as a costimulatory molecule for T cells.
  • To elucidate mechanisms of T cell CD40 function in autoimmunity.

Main Methods:

  • Examined CD40(+) T cells from collagen-induced arthritis mice.
  • Utilized mouse and human T cell lines transfected with CD40.
  • Compared CD40 costimulatory function with CD28.

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Main Results:

  • CD40 demonstrated effective costimulation of T cell receptor (TCR)-mediated activation.
  • CD40 induced kinase and transcription factor activities, and cytokine production.
  • Combined CD40 and CD28 signals with antigen receptor (AgR) stimulation provided additional enhancement.

Conclusions:

  • T cell CD40 possesses potent biologic functions.
  • CD40 serves as a costimulatory molecule on T lymphocytes.
  • T cell CD40 may amplify autoimmune responses.