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Apnea in infants
Adrian Poblano1, Aida Marquez, Guadalupe Hernandez
1Clinic of Sleep Disorders, School of Medicine, National University of Mexico, Mexico City, Mexico. drdeaf@starmedia.com
Insights
Neonatal apnea events affect nearly 25% of infants, with specific types linked to preterm birth, hyperbilirubinemia, and sepsis. Polysomnography identified many cases without prior clinical suspicion.
Area of Science:
- Neonatal Medicine
- Pediatric Pulmonology
- Sleep Medicine
Background:
- Apnea is a common concern in neonatal care units.
- Understanding risk factors for different apnea types is crucial for timely intervention.
Purpose of the Study:
- To determine the frequency of risk factors associated with various apnea types in newborns.
- To analyze polysomnographic (PSG) findings in neonatal intensive care unit (NICU) patients.
Main Methods:
- A prospective study conducted in NICU of a tertiary care institution in Mexico City.
- 223 infants were evaluated using sleep PSG recordings between August 2002 and August 2003.
- Infants presenting any apnea event during PSG were included for analysis.
Main Results:
- Approximately 25% of NICU patients experienced apnea events.
- Infants with apnea had lower birth age, weight, and cephalic perimeter but no increased neurological risk factors.
- Central apnea was linked to preterm birth (<1,500g), obstructive apnea to hyperbilirubinemia and gastro-esophageal reflux, and mixed apnea to sepsis and hyperbilirubinemia.
- PSG revealed 36% of infants with apnea lacked prior clinical suspicion.
Conclusions:
- Central apnea events are more prevalent in preterm infants.
- Obstructive apnea is associated with hyperbilirubinemia and gastro-esophageal reflux.
- Mixed apnea events frequently occur in infants with hyperbilirubinemia and sepsis.
Objective:
The main objective of this study was to describe frequency of risk factors in newborns who present different types of apnea in polysomnographic (PSG) recordings in neonatal care units.
Methods:
The study was carried out in neonatal care units of a perinatal tertiary level institution in Mexico City between August 2002 and August 2003. Infants were selected from among 223 infants if they presented any type of apnea event in sleep PSG recordings.
Results:
Nearly 25% of patients from a neonatal care unit presented apnea events. Infants with apnea showed lower values of age, weight, and cephalic perimeter at birth than infants without apnea, but did not show more neurologic risk factors. Central apnea events were more frequent in infants with preterm birth (birthweight < 1,500 g), obstructive apnea events were observed in infants with hyperbilirubinemia and gastro-esophageal reflux, while mixed events were seen in infants with sepsis, and hyperbilirubinemia. Sleep PSG recordings detected that 36% of infants with apnea have no previous clinic suspicion of the problem.
Conclusion:
Central events of apnea were found more frequent in infants with preterm birth, obstructive events in newborns with hyperbilirubinemia and gastroesophagic reflux, while infants mixed apnea had more frequent hyperbilirubinemia and sepsis.
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