Related Experiment Video
Updated: Jul 17, 2026
07:38
Induction of Nephrotic Syndrome in Mice by Retrobulbar Injection of Doxorubicin and Prevention of Volume Retention by Sustained Release Aprotinin
Published on: May 6, 2018
Rhabdomyolysis caused by hypernatremia.
Faruk Incecik1, M Ozlem Herguner, Dincer Yildizdas
1Cukurova University Medical Faculty, Department of Pediatric Neurology, Adana, Turkey. fincecik@yahoo.com
Indian Journal of Pediatrics
|January 5, 2007
Summary
Rhabdomyolysis, a rare condition in children, can manifest with severe hypernatremia. This case highlights the importance of considering rhabdomyolysis in pediatric patients presenting with extreme sodium levels.
Area of Science:
- Pediatric Nephrology
- Clinical Toxicology
- Emergency Medicine
Background:
- Rhabdomyolysis is a serious clinical syndrome characterized by muscle breakdown.
- Pediatric rhabdomyolysis is infrequently encountered, making its recognition challenging.
- Hypernatremia, particularly severe cases, can be associated with various medical emergencies.
Observation:
- A pediatric patient presented with biochemical and clinical evidence of rhabdomyolysis.
- The patient was admitted to the clinic exhibiting signs of severe hypernatremia.
- This case underscores a rare presentation of rhabdomyolysis in a pediatric context.
Findings:
- The patient displayed significant muscle damage markers consistent with rhabdomyolysis.
- Severe hypernatremia was a prominent feature of the patient's clinical presentation.
- A correlation between severe hypernatremia and the development of rhabdomyolysis was observed.
Implications:
- Clinicians should maintain a high index of suspicion for rhabdomyolysis in children with severe hypernatremia.
- Early recognition and management of rhabdomyolysis are crucial in pediatric cases.
- This case contributes to understanding the rare associations between electrolyte imbalances and muscle injury in children.
Related Concept Videos
01:21Hyperosmolar Hyperglycemic State
Hyperosmolar Hyperglycemic State, or HHS, is a serious and life-threatening complication of type 2 diabetes mellitus. It is characterized by three main features: severe hyperglycemia, profound dehydration, and elevated serum osmolality, all occurring without significant ketoacidosis.HHS typically develops in older adults or individuals with limited access to fluids. This may result from illness, cognitive impairment, or medications such as diuretics or corticosteroids. These factors reduce...
01:24Nephrotic Syndrome I : Introduction
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of fluid...
01:24Hemodialysis II: Procedure and Complications
DialyzersA hemodialysis (HD) dialyzer is a plastic cartridge containing thousands of parallel hollow fibers, which serve as semipermeable membranes. These fibers are typically made from cellulose-based or other synthetic materials. During HD, blood is pumped into the top of the cartridge and distributed among these fibers. Simultaneously, dialysis fluid, known as dialysate, is introduced into the bottom of the cartridge, bathing the outside of the fibers. Across the semipermeable membrane,...
01:29Disorder of Water Balance
Water balance disorders are medical conditions that occur when there is a deviation from the body's water volume or osmolarity, disrupting normal homeostasis and leading todehydration, hypotonic hydration, hyperhydration, edema, or water intoxication.
Dehydration
Dehydration occurs when the body loses fluids (particularly water).
Causes:
The major causes of dehydration include excessive sweating, fever, vomiting, diarrhea, and diuresis.
Signs and Symptoms:
Symptoms primarily include intense...
Dehydration
Dehydration occurs when the body loses fluids (particularly water).
Causes:
The major causes of dehydration include excessive sweating, fever, vomiting, diarrhea, and diuresis.
Signs and Symptoms:
Symptoms primarily include intense...
01:25Regulation of Water Intake
Osmolality refers to the number of solute particles per kilogram of solvent in a solution. Plasma osmolality specifically indicates the total number of solute particles per kilogram of water in blood plasma. This value reflects the body's hydration status and is tightly regulated through mechanisms controlling water intake and output. While water consumption is a conscious decision, the body has intrinsic regulatory systems to maintain fluid balance. Dehydration, a state of water deficit...
01:26Nephrotic Syndrome II : Assessment and Medical Management
IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document any history...