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Updated: Jul 17, 2026

Humanized Mediator Release Assay as a Read-Out for Allergen Potency
Published on: June 29, 2021
[Role of therapeutics for allergic diseases in targeting histamine H1 receptor gene expression]
1Department of Molecular Pharmacology, Graduate School of Health Biosciences, The University of Tokushima, Tokushima City, Japan. hfukui@ph.tokushima-u.ac.jp
Abstract:
Histamine H(1) receptors are down-regulated as one step in receptor desensitization. Five phosphorylation sites of the H(1) receptor seem to play a key role in receptor down-regulation. In contrast, an increase in the H(1) receptor expression level following its mRNA elevation was found in the nasal mucosa in hypersensitivity model rats. Up-regulation of the H(1) receptor was induced by the direct stimulation of the H(1) receptor. H(1) receptor up-regulation was suppressed by pretreatment with antiallergic agents.
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