Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

SUMOylation code in cancer development and metastasis.

Keun Il Kim1, Sung Hee Baek

  • 1Department of Biological Sciences, Research Center for Functional Cellulomics, Seoul National University, Seoul 151-742, Korea. kikim@sookmyung.ac.kr

Molecules and Cells
|January 5, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dual mechanism of autophagy gene repression by PHF23 and therapeutic potential of its inhibition in protein aggregation disorders.

Nucleic acids research·2025
Same author

Dihydroartemisinin inhibits metastatic potential and cancer stemness by modulating the miR-200b-BMI-1/VEGF-A axis in ovarian cancer.

Experimental & molecular medicine·2025
Same author

From static catalogs to dynamic regulation: Comment on "Unlocking the brain's code: The crucial role of post-translational modifications in neurodevelopment and neurological function" by Peng Ye et al.

Physics of life reviews·2025
Same author

A needed nomenclature for nucleosomes.

Molecular cell·2025
Same author

Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation.

FEBS letters·2025
Same author

Identification of KANK1 as a tumor suppressor gene in pancreatic ductal adenocarcinoma.

Biochemical and biophysical research communications·2025
Same journal

Oxidative stress drives liver failure during in vivo partial reprogramming.

Molecules and cells·2026
Same journal

scpp5 regulates tooth development and injury-induced repair in zebrafish through mineralization and Wnt/β-catenin signaling.

Molecules and cells·2026
Same journal

Corrigendum to "Molecular role of developmentally regulated GTP-binding protein 1 in coordinating osteoclast and osteoblast differentiation during bone remodeling" [Mol. Cells 49 (2026) 100342].

Molecules and cells·2026
Same journal

Multiple ShKT domain-containing MUL-1 proteins act as redox-responsive modulators of oxidative stress signaling in C. elegans.

Molecules and cells·2026
Same journal

Small molecule inhibition of voltage dependent anion channel 1 reroutes mitochondrial metabolite flux.

Molecules and cells·2026
Same journal

Adherent-to-suspension transition modulates circulating tumor cell dynamics and metastatic potential in melanoma.

Molecules and cells·2026
See all related articles

The SUMOylation system regulates cellular functions and homeostasis. Dysregulation of SUMOylation or deSUMOylation can lead to cancer development and metastasis.

Area of Science:

  • Biochemistry and Molecular Biology
  • Cellular Biology
  • Cancer Research

Background:

  • Protein modification by SUMOylation (small ubiquitin-like modifier) is crucial for regulating nuclear protein functions.
  • The SUMO system maintains cellular homeostasis and plays a role in DNA damage repair and genome integrity.
  • Aberrant SUMOylation/deSUMOylation processes are implicated in disease states, including cancer.

Purpose of the Study:

  • To review and discuss the role of the SUMO system in cancer development.
  • To explore the involvement of SUMOylation in cancer metastasis.

Main Methods:

  • Literature review and synthesis of existing research on SUMOylation.
  • Analysis of studies linking SUMOylation pathways to cancer initiation and progression.

Related Experiment Videos

  • Examination of evidence for SUMOylation's role in cancer cell metastasis.

    • Main Results:

    • SUMOylation controls diverse cellular functions, impacting transcription factors and coregulators.
    • Loss of SUMOylation control contributes to homeostasis defects, potentially initiating cancer.
    • Emerging evidence highlights the SUMO system's involvement in cancer metastasis.

    Conclusions:

    • The SUMO system is a critical regulator of cellular processes relevant to cancer.
    • Understanding SUMOylation and deSUMOylation is key to deciphering cancer development and metastasis.
    • Targeting the SUMO pathway may offer novel therapeutic strategies for cancer treatment.