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Published on: August 3, 2016
Recently developed GC/MS and LC/MS methods for determining NSAIDs in water samples
M Farré1, M Petrovic, D Barceló
1Department of Environmental Chemistry, IIQAB-CSIC, C/ Jordi Girona 18-26, 08034 Barcelona, Spain.
Analytical and Bioanalytical Chemistry
|January 5, 2007
Summary
Pharmaceuticals in water pose environmental and health risks. Advanced analytical methods like GC-MS/MS and LC-MS/MS are crucial for detecting non-steroidal anti-inflammatory drugs (NSAIDs) at low levels.
Area of Science:
- Environmental Chemistry
- Analytical Chemistry
- Pharmacology
Background:
- Pharmaceuticals are detected in aquatic environments due to incomplete wastewater treatment and contamination.
- Their presence poses risks to drinking water, wildlife, and human health.
- Accurate detection is essential for environmental monitoring and risk assessment.
Purpose of the Study:
- To present advanced analytical methodologies for the determination of non-steroidal anti-inflammatory drugs (NSAIDs).
- To highlight techniques for detecting NSAIDs in the nanogram per litre range.
- To discuss the application of GC-MS, GC-MS/MS, and LC-MS/MS for NSAID analysis.
Main Methods:
- Solid-phase extraction (SPE) or solid-phase microextraction (SPME) for sample preparation.
- Derivatisation techniques to enhance detectability.
- Advanced mass spectrometry methods: Gas Chromatography-Mass Spectrometry (GC-MS), GC-MS/MS, and Liquid Chromatography-Electrospray Tandem Mass Spectrometry (LC-ES/MS/MS).
Main Results:
- Development of methods for detecting drugs and metabolites in the low nanogram per litre range.
- Established the essential role of LC-MS and GC-MS (with derivatisation) for polar NSAIDs.
- Showcased the advanced capabilities of current GC-MS/MS and LC-MS/MS methodologies.
Conclusions:
- Advanced analytical techniques are vital for monitoring pharmaceutical pollution in aquatic environments.
- GC-MS/MS and LC-MS/MS offer high sensitivity and specificity for NSAID determination.
- These methods are critical for assessing environmental risks and ensuring water safety.
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