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Recent advances in surface plasmon resonance based techniques for bioanalysis.

K Scott Phillips1, Quan Cheng

  • 1Department of Chemistry, University of California, Riverside, CA 92521, USA.

Analytical and Bioanalytical Chemistry
|January 5, 2007
PubMed
Summary
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Surface plasmon resonance (SPR) advances biomolecular interaction analysis (BIA) through new materials and methods. This review highlights innovations in SPR spectroscopy and imaging, paving the way for broader biosensing applications.

Area of Science:

  • Spectroscopy
  • Biomolecular Interaction Analysis
  • Biosensing

Background:

  • Surface plasmon resonance (SPR) is a well-established spectroscopic technique for biomolecular interaction analysis (BIA).
  • Previous reviews have covered its foundational aspects.
  • This 2006 review focuses on recent technological advancements and applications.

Purpose of the Study:

  • To review cutting-edge developments in SPR, SPR spectroscopy, and SPR imaging.
  • To highlight advancements in materials, methods, and instrumentation for SPR.
  • To showcase recent applications in bioanalysis.

Main Methods:

  • Review of recent literature on SPR technology and applications.
  • Detailed discussion of three focus topics: surface plasmon fluorescence spectroscopy, nanoscale glassification of SPR substrates, and enzymatic amplification in SPR imaging.

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Main Results:

  • Significant progress in SPR-based methods and diversification of applications.
  • Emerging trends include combined techniques, novel materials, and new methodologies.
  • Developments in surface plasmon fluorescence spectroscopy, nanoscale glassification, and enzymatic amplification in SPR imaging.

Conclusions:

  • SPR technology continues to evolve rapidly.
  • SPR-based methods are becoming more versatile and widely applicable.
  • The future outlook for SPR and associated BIA is highly promising for surface interaction analysis and biosensing.