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Acute liver failure due to leptospirosis successfully treated with MARS (molecular adsorbent recirculating system)

Adrian Covic1, Irinel-Doina Maftei, Paul Gusbeth-Tatomir

  • 1Dialysis Center, Dr. C. I. Parhon University Hospital, Iasi, Romania.

International Urology and Nephrology
|January 5, 2007
PubMed
Abstract

Insights

Severe leptospirosis can cause multiple organ failure. Albumin dialysis using the Molecular Adsorbent Recirculating System (MARS) successfully treated acute liver and kidney failure in a patient with leptospirosis.

Area of Science:

  • Infectious Diseases
  • Nephrology
  • Hepatology

Background:

  • Leptospirosis is a re-emerging infectious disease with potential for severe complications, including multiple organ failure.
  • Acute liver failure (ALF) and acute kidney injury (AKI) are critical manifestations of severe leptospirosis.

Observation:

  • A case of severe leptospirosis complicated by hepatic encephalopathy grade III, hypoglycemia, hyperbilirubinemia, and coagulopathy is presented.
  • Despite conventional treatments including antibiotics, supportive care, and hemodialysis, the patient experienced progressive liver failure.

Findings:

  • The patient underwent two sessions of albumin dialysis with the Molecular Adsorbent Recirculating System (MARS).
  • Following MARS treatment, complete recovery of both hepatic and renal functions was observed.

Implications:

  • Albumin dialysis with MARS may offer a significant survival benefit for patients with leptospirosis-induced ALF.
  • This case highlights MARS as a potential therapeutic option for severe leptospirosis with organ dysfunction.

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