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Methotrexate-added acrylic cement: biological and physical properties
G Maccauro1, A Cittadini, M Casarci
1Department of Orthopaedics, Catholic University, Rome, Italy. giuliomac@tiscali.it
Journal of Materials Science. Materials in Medicine
|January 5, 2007
Summary
Methotrexate (MTX) supplemented acrylic cement effectively delivers the active drug over time for bone metastases treatment. Crucially, MTX elution does not compromise the cement's structural integrity, supporting its clinical use.
Area of Science:
- Oncology
- Biomaterials Science
- Drug Delivery
Background:
- Acrylic cement is used to deliver chemotherapeutic drugs for bone metastases.
- Methotrexate (MTX) has shown promise for elution from acrylic cement.
- This study investigates MTX-cement suitability for local adjuvant chemotherapy.
Purpose of the Study:
- To evaluate the efficacy of methotrexate (MTX) incorporated into acrylic cement for local adjuvant chemotherapy.
- To assess the elution kinetics and cytotoxic activity of MTX from acrylic cement.
- To determine the impact of MTX addition on the mechanical properties of acrylic cement.
Main Methods:
- An in vitro model using human breast cancer cells was employed.
- Drug elution kinetics and cytotoxic effects were monitored over time.
- Mechanical properties, specifically compressive strength, were evaluated.
Main Results:
- Methotrexate is released in an active, cytotoxic form over an extended period.
- Elution rates are dependent on drug concentration and decrease over time.
- Incorporation of MTX does not negatively affect the compressive properties of the acrylic cement.
Conclusions:
- Methotrexate-supplemented acrylic cement is suitable for local adjuvant chemotherapy.
- This approach supports the management of bone metastases requiring surgical curettage and cement implantation.
- The findings validate MTX-cement as an effective therapeutic option for bone metastases.
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