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Related Experiment Videos

Abnormalities in CD4+ T lymphocyte subsets in patients with common variable immunodeficiency.

Y Lebranchu1, G Thibault, D Degenne

  • 1Department of Immunology, Faculté de Médecine, Tours, France.

Clinical Immunology and Immunopathology
|October 1, 1991
PubMed
Summary

Common Variable Immunodeficiency (CVI) is linked to fewer CD4+ CD45RA+ T cells, impacting T cell function and antibody production. This T cell subset deficiency may explain the impaired immunoglobulin levels in CVI patients.

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Reply: To PMID 23918413.

Arthritis & rheumatology (Hoboken, N.J.)·2014

Area of Science:

  • Immunology
  • Cell Biology

Background:

  • Common Variable Immunodeficiency (CVI) is characterized by hypogammaglobulinemia.
  • The role of T cell defects in CVI pathogenesis remains incompletely understood.

Purpose of the Study:

  • To investigate the T cell phenotype and function in CVI patients.
  • To determine if T cell abnormalities correlate with immunoglobulin deficiency.

Main Methods:

  • Analysis of peripheral blood mononuclear cells (PBMC) from 9 CVI patients and 12 healthy controls.
  • Flow cytometry was used to assess T cell subsets (CD3+, CD8+, CD4+, CD4+CD45RA+, CD4+CD29+).
  • PBMC proliferative responses to mitogens (PHA, Con A) were measured.

Main Results:

  • CVI patients showed significantly decreased numbers of CD4+ T cells compared to controls.

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  • This reduction was primarily due to a deficiency in the naive CD4+CD45RA+ T cell subset.
  • A positive correlation was observed between CD4+CD45RA+ T cell levels and PBMC proliferative responses.

    • Conclusions:

    • A significant decrease in CD4+CD45RA+ T cells is a key feature in CVI.
    • This T cell subset deficiency may contribute to impaired T cell function and antibody production in CVI.