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Related Experiment Videos

Conditional mouse models of cancer.

D Vignjevic1, S Fre, D Louvard

  • 1Equipe de Morphogenèse et Signalisation cellulaires, UMR 144 CNRS, Institut Curie, 25 rue d'Ulm, 75248 Paris 05, France.

Handbook of Experimental Pharmacology
|January 6, 2007
PubMed
Summary
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Advanced transgenic mouse models now accurately mimic human cancers, including colon cancer. These models enable in vivo tracking of tumor growth and drug testing for targeted therapies.

Area of Science:

  • Oncology
  • Genetics
  • Translational Medicine

Background:

  • Inducible and conditional technologies have revolutionized the creation of genetically engineered mouse models.
  • These mouse models now faithfully recapitulate human tumorigenesis across various tissues.

Purpose of the Study:

  • To review the development and application of mouse models for human cancer, with a focus on colon cancer.
  • To highlight the utility of these models for studying tumor development, metastasis, and therapeutic responses.

Main Methods:

  • Utilizing inducible and conditional technologies to generate transgenic mouse models.
  • Employing noninvasive imaging techniques for in vivo monitoring of tumor progression and drug efficacy.

Main Results:

Related Experiment Videos

  • Availability of mouse models for most major human cancers, including colon cancer.
  • Capability to control tumor development in specific tissues, times, and spatial locations.
  • Enabling in vivo tracking of tumor development, metastasis, and therapeutic drug effects.

Conclusions:

  • New generation mouse models accurately emulate human cancer in situ.
  • These models serve as valuable platforms for testing targeted drugs and gene-combination therapies.
  • Focus on colon cancer models provides a specific example of their application in oncology research.