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Mouse Models of Cancer Study

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

Mouse Models of Cancer Study

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

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Related Experiment Video

Updated: Jul 17, 2026

A Genetically Engineered Mouse Model of Sporadic Colorectal Cancer

A Genetically Engineered Mouse Model of Sporadic Colorectal Cancer

Published on: July 6, 2017

Conditional mouse models of cancer.

D Vignjevic¹, S Fre, D Louvard

¹Equipe de Morphogenèse et Signalisation cellulaires, UMR 144 CNRS, Institut Curie, 25 rue d'Ulm, 75248 Paris 05, France.

Handbook of Experimental Pharmacology

|January 6, 2007

Summary

Advanced transgenic mouse models now accurately mimic human cancers, including colon cancer. These models enable in vivo tracking of tumor growth and drug testing for targeted therapies.

Area of Science:

Oncology
Genetics
Translational Medicine

Background:

Inducible and conditional technologies have revolutionized the creation of genetically engineered mouse models.
These mouse models now faithfully recapitulate human tumorigenesis across various tissues.

Purpose of the Study:

To review the development and application of mouse models for human cancer, with a focus on colon cancer.
To highlight the utility of these models for studying tumor development, metastasis, and therapeutic responses.

Main Methods:

Utilizing inducible and conditional technologies to generate transgenic mouse models.
Employing noninvasive imaging techniques for in vivo monitoring of tumor progression and drug efficacy.

Main Results:

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Availability of mouse models for most major human cancers, including colon cancer.
Capability to control tumor development in specific tissues, times, and spatial locations.
Enabling in vivo tracking of tumor development, metastasis, and therapeutic drug effects.

Conclusions:

New generation mouse models accurately emulate human cancer in situ.
These models serve as valuable platforms for testing targeted drugs and gene-combination therapies.
Focus on colon cancer models provides a specific example of their application in oncology research.