Infective disorders of the gastrointestinal tract

L W Lamps1

  • 1Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA. lampslauraw@uams.edu

Histopathology
|January 6, 2007
PubMed

Insights

Surgical pathologists aid in diagnosing gastrointestinal infections, particularly enterocolitis from food/water pathogens. Histological features are key, even when mimicking other gut conditions.

Area of Science:

  • Gastroenterology
  • Pathology
  • Infectious Diseases

Background:

  • Gastrointestinal infections cause significant global morbidity and mortality.
  • Microbiological methods are standard for pathogen recovery.
  • Surgical pathology offers valuable diagnostic insights.

Purpose of the Study:

  • To review infective gastrointestinal disorders, focusing on food- and water-borne enterocolitis.
  • To highlight diagnostic histological features of enteric infections.
  • To discuss diagnostic methods aiding pathologists.

Main Methods:

  • Review of literature on gastrointestinal infections and pathology.
  • Emphasis on histological findings in enterocolitis.
  • Discussion of diagnostic techniques for enteric pathogens.

Main Results:

  • Surgical pathology provides crucial diagnostic information for gastrointestinal infections.
  • Histological features can identify specific food- and water-borne pathogens.
  • Certain infections present with features mimicking other gastrointestinal inflammatory diseases.

Conclusions:

  • Pathologists play a vital role in diagnosing gastrointestinal infections.
  • Histopathology is essential for identifying enteric pathogens and differentiating mimics.
  • Integrated diagnostic approaches enhance patient care for infectious enterocolitis.

Related Concept Videos

Bacterial Gastroenteritis01:18

Bacterial Gastroenteritis

Bacterial gastroenteritis, characterized by diarrhea, abdominal cramps, and vomiting, is often caused by ingestion of contaminated food or water and is frequently associated with pathogenic Escherichia coli strains. These microbes exploit two principal mechanisms to inflict disease.Shiga toxin–producing E. coli, also referred to as STEC—notably O157:H7—release Shiga toxins that target ribosomes, blocking protein synthesis. The B subunit of the toxin binds the host glycolipid receptor...
Other Disorders of Digestive System01:30

Other Disorders of Digestive System

The gastrointestinal tract is susceptible to various disorders. If the lower esophageal sphincter is damaged, stomach acid can flow back into the esophagus, causing irritation and inflammation of the lining. This condition is called gastroesophageal reflux disease (known as heartburn) and may cause chest pain and difficulty swallowing. In the stomach, prolonged use of nonsteroidal anti-inflammatory drugs like aspirin, chronic alcohol consumption, bacterial infections such as Helicobacter...
Gastrointestinal Motility Disorders01:20

Gastrointestinal Motility Disorders

Gastrointestinal or GI motility disorders are characterized by irregular gastrointestinal tract movements, disrupting food transit from the mouth to the anus. They are caused by damage or dysfunction in gut muscles or nerves. These disorders can cause symptoms such as severe constipation, diarrhea, abdominal pain, and swallowing difficulties. Disorders can affect any segment of the GI tract and range widely in severity, from common conditions like GERD to life-threatening conditions like...
Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
Giardiasis01:12

Giardiasis

Giardiasis is a globally prevalent intestinal infection caused by the protozoan parasite Giardia duodenalis (also known as G. lamblia or G. intestinalis). This flagellated protozoan is the most frequently identified intestinal parasite in the United States and worldwide. Transmission primarily occurs via the fecal-oral route, with infection arising from ingestion of water or food contaminated with cysts. Individuals in low-resource settings, international travelers, outdoor enthusiasts, daycare...
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...