Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Histology of the Small Intestine

Histology of the Small Intestine

The small intestine exhibits a unique histological structure that significantly enhances its function in digestion and nutrient absorption. These structures include circular folds, villi, and various specialized cells that collectively facilitate the digestion of food.
The intestinal lining features transverse folds called circular folds, each housing fingerlike projections known as intestinal villi. These villi are covered by a layer of simple columnar epithelium, also referred to as...

Mucosal Barrier of the Stomach

Mucosal Barrier of the Stomach

The gastric glands contain parietal cells that secrete hydrochloric acid (HCl) for digestion. The cells secrete HCl because it is highly corrosive and essential for breaking down food. To achieve this, they secrete hydrogen and chloride ions into the lumen of the gastric glands, which combine to form HCl.
Within parietal cells, carbonic acid is first formed through the reaction of water and carbon dioxide. The dissociation of carbonic acid releases bicarbonate and hydrogen ions. The bicarbonate...

Appendicitis

Appendicitis

Appendicitis is an acute inflammatory condition of the vermiform appendix, most commonly caused by obstruction of its lumen. The appendix is a narrow, blind-ended pouch that extends from the cecum, making it particularly prone to obstruction. Causes include fecaliths, lymphoid hyperplasia (often after viral infections), parasites, tumors, or foreign bodies. This obstruction initiates a cascade of pathological changes.Luminal Obstruction and Early InflammationAfter obstruction, normal mucosal...

Histology of the Gastrointestinal (GI) Tract

Histology of the Gastrointestinal (GI) Tract

The GI tract, from beginning to end, is made up of four continuous tissue layers that adjust their structure according to their specific roles. These layers, from innermost to outermost, are known as the mucosa, submucosa, muscularis, and serosa, which are continuous with the mesentery.
The mucosa is sometimes called a mucous membrane due to its mucus-secreting features. This membrane is composed of epithelium, which directly interacts with ingested substances, and the lamina propria, a layer...

Histology of the Large Intestine

Histology of the Large Intestine

The large intestine, a vital component of the gastrointestinal tract, is structured with four main layers: the mucosa, submucosa, muscularis, and serosa. Each layer performs a distinct role in facilitating the smooth functioning of the large intestine.
The innermost mucosa layer comprises simple columnar epithelium, lamina propria, and muscularis mucosae. This layer is primarily populated with absorptive cells, tasked with water absorption, and goblet cells, responsible for secreting mucus to...

Cellular Adaptation IV: Dysplasia and Metaplasia

Cellular Adaptation IV: Dysplasia and Metaplasia

DysplasiaDysplasia refers to abnormal changes in the size, shape, and organization of mature cells, characterized by pleomorphism, nuclear abnormalities, and increased mitotic activity. It commonly affects epithelial tissues, including the cervix, gastrointestinal tract, respiratory mucosa, and endometrium. Although it may occur alongside hyperplasia, dysplasia is not a true adaptive response but a preneoplastic change with potential to progress to cancer.When confined above the basement...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A Pathological Rose by Any Other Name.

West of England medical journal·2017

Same author

The proportion of tumor-stroma as a strong prognosticator for stage II and III colon cancer patients: validation in the VICTOR trial.

Annals of oncology : official journal of the European Society for Medical Oncology·2012

Same author

Quality control in upper gastrointestinal endoscopy: detection rates of gastric cancer in Oxford 2005-2008.

Postgraduate medical journal·2011

Same author

European evidence-based Consensus on the diagnosis and management of ulcerative colitis: Definitions and diagnosis.

Journal of Crohn's & colitis·2010

Same author

Are we reporting ileal pouch biopsies correctly?

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland·2010

Same author

Delayed surgery for acute severe colitis is associated with increased risk of postoperative complications.

The British journal of surgery·2010

Search research articles

Related Experiment Video

Updated: Jul 17, 2026

Visualization of Gut Microbiota-host Interactions via Fluorescence In Situ Hybridization, Lectin Staining, and Imaging

Visualization of Gut Microbiota-host Interactions via Fluorescence In Situ Hybridization, Lectin Staining, and Imaging

Published on: July 9, 2021

Histopathological mimicry in mucosal prolapse.

B Singh¹, N J McC Mortensen, B F Warren

¹Nuffield Department of Surgery, John Radcliffe Hospital, Oxford, UK.

|January 6, 2007

Summary

Solitary rectal ulcer syndrome (SRUS) presents diagnostic challenges for pathologists and surgeons. Accurate diagnosis of SRUS is crucial to prevent unnecessary surgeries and side effects of long-term treatments.

Area of Science:

Gastroenterology
Colorectal Surgery
Surgical Pathology

Background:

Solitary rectal ulcer syndrome (SRUS) is a rare but challenging anorectal disorder.
Despite being recognized for over a century, SRUS remains a diagnostic dilemma for clinicians.
Misdiagnosis can lead to inappropriate interventions, increasing patient morbidity.

Purpose of the Study:

To review the histological features of mucosal prolapse in SRUS.
To highlight how these features can be mistaken for other pathological conditions.
To emphasize the importance of accurate SRUS diagnosis.

Main Methods:

Review of existing literature on SRUS and mucosal prolapse.
Analysis of histological findings associated with SRUS.

More Related Videos

Diagnosis of Neoplasia in Barrett’s Esophagus using Vital-dye Enhanced Fluorescence Imaging

Diagnosis of Neoplasia in Barrett’s Esophagus using Vital-dye Enhanced Fluorescence Imaging

Published on: May 11, 2014

Related Experiment Videos

Last Updated: Jul 17, 2026

Visualization of Gut Microbiota-host Interactions via Fluorescence In Situ Hybridization, Lectin Staining, and Imaging

Visualization of Gut Microbiota-host Interactions via Fluorescence In Situ Hybridization, Lectin Staining, and Imaging

Published on: July 9, 2021

Diagnosis of Neoplasia in Barrett’s Esophagus using Vital-dye Enhanced Fluorescence Imaging

Diagnosis of Neoplasia in Barrett’s Esophagus using Vital-dye Enhanced Fluorescence Imaging

Published on: May 11, 2014

Comparison of SRUS histology with other rectal pathologies.

Main Results:

Mucosal prolapse is a key feature in SRUS.
Histological findings in SRUS can mimic other conditions, leading to diagnostic confusion.
Correct identification of SRUS histology is essential for appropriate patient management.

Conclusions:

Accurate histological interpretation is vital for diagnosing SRUS.
Distinguishing SRUS from other rectal pathologies avoids suboptimal treatment and surgical risks.
Improved understanding of SRUS histology can enhance diagnostic accuracy and patient outcomes.