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VEGF, FGF1, FGF2 and EGF gene polymorphisms and psoriatic arthritis
Christopher Butt1, Sooyeol Lim, Celia Greenwood
1Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St. John's, Newfoundland and Labrador, Canada. cbutt@mun.ca <cbutt@mun.ca>
The T allele of vascular endothelial growth factor (VEGF) at +936 may protect against psoriatic arthritis (PsA). This finding suggests a potential role for VEGF in PsA development, warranting further investigation into angiogenic factors.
Area of Science:
- Genetics
- Immunology
- Rheumatology
Background:
- Angiogenesis is a key process in psoriatic arthritis (PsA) pathogenesis.
- Key angiogenic factors include vascular endothelial growth factor (VEGF), epidermal growth factor (EGF), and fibroblast growth factors (FGF1, FGF2).
- These factors are implicated in related inflammatory conditions like psoriasis, rheumatoid arthritis, and ankylosing spondylitis.
Purpose of the Study:
- To investigate the association between specific genetic variations in angiogenic factor genes and PsA.
- To evaluate the role of VEGF, EGF, FGF1, and FGF2 gene polymorphisms in PsA susceptibility.
Main Methods:
- Genotyping of 258 PsA patients and 154 controls using MALDI-TOF mass spectrometry.
- Analysis of single nucleotide polymorphisms (SNPs) in VEGF, EGF, FGF1, and FGF2 genes.
- Statistical analysis included Fisher's exact test, Cochrane-Armitage trend test, and haplotype analysis.
Main Results:
- An increased frequency of the T allele of VEGF +936 (rs3025039) was observed in controls compared to PsA patients (p=0.042).
- The odds ratio for the protective T allele was 0.653 (95% CI: 0.434, 0.982).
- No significant associations were found through haplotype analysis.
Conclusions:
- The T allele of VEGF at +936 may confer a protective effect against the development of PsA.
- Further research is needed to elucidate the role of pro-angiogenic markers in PsA.
- VEGF genetic variations could be potential biomarkers for PsA risk.
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