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[TGF-beta signaling during hematopoietic development--review]

Yu Lan1, Xiao Yang

  • 1Department of Genetics of Development and Diseases, Institute of Biotechnology, Academy of Military Medical Sciences, Beijing 100071, China.

Zhongguo Shi Yan Xue Ye Xue Za Zhi
|January 6, 2007
PubMed

Hematopoietic development is characterized by the dynamic generation of hematopoietic stem/progenitor cells during embryogenesis, and afterward, the maintaining of hematopoietic homeostasis in adult. Mouse model has been appreciated valuable for dissecting the regulatory mechanisms of hematopoietic development. As an important cytokine playing pivotal and versatile roles in the regulation of hematopoiesis, transforming growth factor-beta (TGF-beta) attracts more and more attention. In particular, gene targeting by homologous recombination provides a key means for systematic evaluation of how TGF-beta signaling is involved in hematopoiesis under physiological conditions. To further illustrate the functions and possible mechanisms of TGF-beta in hematopoietic development, hematopoietic phenotypes of targeted mutations and/or dominant negative transgenes of molecules within the TGF-beta signaling pathway are categorized and discussed in this review.

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