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Updated: Jul 17, 2026
11:42
Hemogenic Reprogramming of Human Fibroblasts by Enforced Expression of Transcription Factors
Published on: November 4, 2019
[TGF-beta signaling during hematopoietic development--review].
1Department of Genetics of Development and Diseases, Institute of Biotechnology, Academy of Military Medical Sciences, Beijing 100071, China.
Zhongguo Shi Yan Xue Ye Xue Za Zhi
|January 6, 2007
Summary
Transforming growth factor-beta (TGF-beta) is crucial for hematopoietic development and homeostasis. This review categorizes hematopoietic phenotypes from gene-targeted mutations in the TGF-beta signaling pathway to elucidate its functions.
Area of Science:
- Hematology
- Developmental Biology
- Molecular Biology
Context:
- Hematopoietic development involves generating stem/progenitor cells during embryogenesis and maintaining adult hematopoietic homeostasis.
- Mouse models are valuable for studying hematopoietic development regulation.
- Transforming growth factor-beta (TGF-beta), a versatile cytokine, plays pivotal roles in hematopoiesis.
Purpose:
- To systematically evaluate the involvement of TGF-beta signaling in hematopoiesis under physiological conditions using gene targeting.
- To illustrate the functions and mechanisms of TGF-beta in hematopoietic development.
Summary:
- This review categorizes hematopoietic phenotypes resulting from targeted mutations and/or dominant-negative transgenes within the TGF-beta signaling pathway.
- It provides insights into how TGF-beta signaling regulates hematopoietic stem/progenitor cell generation and homeostasis.
Impact:
- Enhances understanding of TGF-beta's role in blood cell formation and maintenance.
- Provides a resource for researchers investigating TGF-beta signaling in hematological development and disease.
- Informs potential therapeutic strategies targeting TGF-beta in hematopoietic disorders.
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