Related Experiment Video
Updated: Jul 17, 2026

In Vitro Aggregation Assays Using Hyperphosphorylated Tau Protein
Published on: January 2, 2015
Phenotypic associations of tau and ApoE in Parkinson's disease
Spiridon Papapetropoulos1, Matthew J Farrer, Jeremy T Stone
1Department of Neurology, University of Miami, Miller School of Medicine, Miami, FL 33136, United States. spapapetropoulos@med.miami.edu
Abstract:
Overlaps in clinical, pathological and molecular features of Parkinson's disease (PD), dementing and motor tauopathies have prompted association studies in search of common genetic risk factors that may predispose or modify this spectrum of disorders. To explore possible phenotypic implications, we studied common tau and ApoE gene polymorphisms, associated with Alzheimer's disease (AD), progressive supranuclear palsy (PSP) and PD, in a clinically and pathologically characterized cohort of PD patients and aged control subjects. Our results reveal a novel association between PD-related hallucinations and H1H1 genotype. We also report an association between PDD and the presence of the ApoE epsilon4 allele. Better determination of subsets of PD patients based upon the presence of specific phenotypic features may improve the accuracy of association studies.
Related Concept Videos
Parkinson Disease ll: Pathophysiology
Alzheimer Disease l: Introduction
Parkinson Disease l: Introduction
Alzheimer Disease ll: Pathophysiology
Alzheimer's Disease: Overview
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ and tau...
Parkinson's Disease: Overview
