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Developmental changes in odor-evoked activity in rat piriform cortex.

K R Illig1

  • 1Department of Psychology, University of Virginia, 102 Gilmer Hall, PO Box 400400, Charlottesville, VA 22904-4400, USA. krillig@virginia.edu

Neuroscience
|January 6, 2007
PubMed
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Early rat brain development shows distinct odor-evoked activity patterns in the anterior piriform cortex (APC) that mature over time. These developing neural circuits are crucial for olfactory learning in young rats.

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Olfactory System Research

Background:

  • Odor-evoked Fos protein expression reveals functional subregions in adult rat anterior piriform cortex (APC).
  • Spatial organization of activated cells in posterior piriform cortex (PPC) differs from APC.
  • Developmental changes in olfactory cortex organization are not fully understood.

Purpose of the Study:

  • To investigate odor-evoked Fos expression patterns in the developing rat olfactory cortex.
  • To determine if functionally distinct subregions in APC are present early in postnatal life.
  • To track developmental changes in these patterns and their relation to olfactory learning.

Main Methods:

  • Assessed Fos protein expression in response to aliphatic acid odors in rats from postnatal day 3 (P3) to P10.

Related Experiment Videos

  • Examined Fos-immunoreactive cell distribution in the olfactory bulb and piriform cortex (APC and PPC).
  • Compared developmental patterns with adult Fos expression patterns.

    • Main Results:

    • Fos-positive cells were observed in olfactory bulb layers from the earliest ages.
    • Early postnatal APC showed a central band of Fos-positive cells, differing from the adult pattern.
    • By P10, APC activation patterns shifted to resemble the adult organization (cell-poor central band flanked by cell-rich bands).

    Conclusions:

    • Functionally distinct subregions in APC, identified by odor-evoked Fos expression, are present and active shortly after birth.
    • Developmental shifts in APC activity patterns correlate with the emergence of adult-like olfactory learning behaviors.
    • These maturational changes in neural activity may underlie the development of olfactory learning.