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Related Experiment Videos

Benign prostatic hyperplasia: pathogenesis and medical therapy.

J Geller1

  • 1Department of Medical Education, Mercy Hospital and Medical Center, San Diego, CA 92103-2180.

Journal of the American Geriatrics Society
|December 1, 1991
PubMed
Summary

Testosterone and dihydrotestosterone (DHT) play key roles in benign prostatic hyperplasia (BPH) development. Treatments targeting androgen action reduce prostate size and improve symptoms in about half of patients.

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Area of Science:

  • Endocrinology
  • Urology
  • Androgen Biology

Background:

  • Epidemiologic studies in castrates highlight the testis's role in benign prostatic hyperplasia (BPH) pathogenesis.
  • Both androgens and estrogens secreted by the testis are implicated in BPH.
  • Dihydrotestosterone (DHT) is strongly supported as a key factor, with potential for elevated levels in BPH tissue.

Purpose of the Study:

  • To assess the validity of the DHT theory in BPH pathogenesis.
  • To evaluate the efficacy of androgen-mediated action suppression in treating BPH.

Main Methods:

  • Utilized new techniques to quantify prostate size and function.
  • Administered drugs to suppress androgen action via various mechanisms: blocking androgen secretion, inhibiting 5 alpha-reductase, or blocking DHT receptors.

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  • Conducted double-blind, large multicenter studies.

    • Main Results:

    • Drugs decreased prostate size by approximately 30%.
    • Significant improvement in clinical symptoms of prostatism observed in about 50% of patients.
    • Results suggest a crucial role for androgens, especially DHT, in BPH.

    Conclusions:

    • Androgen suppression is a valid therapeutic approach for BPH, improving symptoms and reducing prostate size.
    • The findings support the DHT theory but indicate that other factors may also contribute to BPH pathogenesis.
    • Further research is exploring the roles of estrogen and alpha-adrenergic regulation in BPH.