Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Calmodulin-dependent Signaling01:16

Calmodulin-dependent Signaling

Calmodulin (CaM) is a calcium-binding protein in eukaryotes that controls various calcium-regulated cellular processes. It has four calcium-binding sites that bind calcium to form the calcium-calmodulin ( Ca2+-CaM) complex. GPCR stimulation increases the calcium levels in the cells that bind to CaM and induces a conformational change.
The Ca2+-CaM complex does not have enzymatic activity by itself. Instead, the complex binds downstream target proteins, including membrane proteins or enzymes,...
Pulmonary Function Tests01:25

Pulmonary Function Tests

Pulmonary Function Tests (PFTs)
Pulmonary Function Tests are crucial diagnostic tools for assessing respiratory function, particularly in patients with chronic respiratory disorders. They comprehensively evaluate lung volumes, ventilatory function, breathing mechanics, diffusion, and gas exchange. These tests help diagnose pulmonary diseases and play a significant role in monitoring disease progression, evaluating disability, and assessing response to therapy.
PFTs involve using a spirometer, a...
Overview of Secretory Vesicles01:33

Overview of Secretory Vesicles

Secretory vesicles, also known as dense core vesicles (DCVs), are membrane-bound vesicles that transport secretory proteins, such as hormones or neurotransmitters. Regulated secretory vesicles transport proteins from the trans-Golgi network to the exterior of the cell. Proteins present in regulated secretory vesicles are required to be rapidly exocytosed in large amounts upon a specific stimulus.
Various proteins regulate the aggregation of molecules inside the secretory vesicles. Chromogranins...
Pharmacogenetics of Drug Transporters: P-Glycoprotein and Solute Carrier Transporters01:16

Pharmacogenetics of Drug Transporters: P-Glycoprotein and Solute Carrier Transporters

The pharmacogenetics of drug transporters is increasingly recognized as a critical factor influencing interindividual variability in drug absorption, distribution, and elimination. These membrane-bound proteins regulate drugs' movement across cellular barriers by actively pumping them out (efflux) or facilitating their uptake (influx). Among the major transporter families, ATP-binding cassette (ABC) and solute carrier (SLC) transporters play particularly prominent roles. Genetic polymorphisms...
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase01:11

Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase

Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

OmiXAI: An ensemble XAI pipeline for interpretable deep learning in omics data.

Scientific reports·2026
Same author

Orforglipron for the treatment of moderate-to-severe obstructive sleep apnea in adults with obesity or overweight: Study design and baseline characteristics of ATTAIN-OSA, a phase 3 trial.

Contemporary clinical trials communications·2026
Same author

Effect of CPAP on a marker of endothelial inflammation differs by OSA-related CVD risk markers.

Annals of the American Thoracic Society·2026
Same author

Zα and Zβ domains of ADAR1 and ZBP1 bind G-quadruplexes with nanomolar affinities, establishing Zβ as a G-quadruplex-specific domain.

Nucleic acids research·2026
Same author

With great power comes great responsibility: the UK Biobank sleep dataset.

Sleep·2026
Same author

Shared genetic architecture between sleep traits and cardiometabolic diseases.

EBioMedicine·2026

Related Experiment Video

Updated: Jul 17, 2026

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment
07:26

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment

Published on: July 18, 2017

Secreted modular calcium-binding protein 2 haplotypes are associated with pulmonary function.

Jemma B Wilk1, Alan Herbert, Christina M Shoemaker

  • 1Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA.

American Journal of Respiratory and Critical Care Medicine
|January 6, 2007
PubMed
Summary

Genetic variations in the SMOC2 gene are associated with lung function measures, specifically forced expiratory volume in 1 second (FEV(1)) and forced vital capacity (FVC). These findings suggest SMOC2

More Related Videos

Primary Sjogren's Syndrome Associated with Lung Adenocarcinoma: Probing the Potential Common Pathogenic Mechanisms and Experimental Verification
10:21

Primary Sjogren's Syndrome Associated with Lung Adenocarcinoma: Probing the Potential Common Pathogenic Mechanisms and Experimental Verification

Published on: September 20, 2024

Related Experiment Videos

Last Updated: Jul 17, 2026

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment
07:26

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment

Published on: July 18, 2017

Primary Sjogren's Syndrome Associated with Lung Adenocarcinoma: Probing the Potential Common Pathogenic Mechanisms and Experimental Verification
10:21

Primary Sjogren's Syndrome Associated with Lung Adenocarcinoma: Probing the Potential Common Pathogenic Mechanisms and Experimental Verification

Published on: September 20, 2024

Area of Science:

  • Genetics and Pulmonary Medicine
  • Molecular Biology and Respiratory Health

Background:

  • Previous linkage analysis in the Framingham Heart Study (FHS) identified a quantitative trait locus for FEV(1) on chromosome 6q27.
  • This locus prompted investigation of the SMOC2 gene as a potential candidate gene influencing lung function.

Purpose of the Study:

  • To investigate the association between single-nucleotide polymorphisms (SNPs) in the SMOC2 gene and lung function parameters, namely FEV(1) and FVC.
  • To analyze these associations in unrelated participants from the Framingham Heart Study.

Main Methods:

  • Genotyping of twenty SNPs located around the SMOC2 gene in 1,734 FHS participants.
  • Statistical analysis using multiple linear regression models, adjusting for covariates such as age, sex, BMI, height, and smoking status.
  • Stratified analyses were performed for ever-smokers and never-smokers.

Main Results:

  • The minor allele of SNP rs1402 showed a significant association with higher mean FEV(1) (p=0.003) and FVC (p=0.02).
  • In never-smokers, the minor allele of SNP rs747995 was associated with increased FEV(1) (p=0.0006) and FVC (p=0.0008).
  • A common G-T haplotype (rs747995-rs1402) in never-smokers was associated with reduced FEV(1) (126 ml, p=0.0002) and FVC (157 ml, p=0.0002), findings replicated in the Family Heart Study.

Conclusions:

  • The study provides evidence for an association between SMOC2 gene polymorphisms and lung function (FEV(1) and FVC).
  • Replication of findings in an independent cohort strengthens the hypothesis that SMOC2 plays a role in determining lung function.
  • These results highlight SMOC2 as a potential genetic factor influencing respiratory health.