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Related Experiment Video

Updated: Jul 17, 2026

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders

Published on: June 8, 2014

Klotho gene polymorphism and male bone mass.

M T Zarrabeitia¹, J L Hernández, C Valero

¹Unit of Legal Medicine, University of Cantabria, Av. Herrera Oria s/n, 39008 Santander, Spain.

Calcified Tissue International

|January 6, 2007

Summary

Klotho gene variants influence bone mineral density (BMD) in younger and middle-aged men. This genetic factor impacts bone mass but not in older men, suggesting a role in adult male skeletal health.

Related Experiment Videos

Last Updated: Jul 17, 2026

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders

Published on: June 8, 2014

Area of Science:

Genetics
Bone Biology
Aging Research

Background:

The Klotho gene plays a role in tissue homeostasis and aging.
Previous studies linked Klotho variants to bone mineral density (BMD) in women.
The impact of Klotho gene polymorphisms on male BMD remains less understood.

Purpose of the Study:

To investigate the association between a common Klotho T/G polymorphism (F/V substitution) and BMD in Spanish men.
To determine if Klotho allelic variants are a genetic factor influencing male bone mass.

Main Methods:

Dual-energy X-ray absorptiometry (DXA) measured BMD in 362 Spanish men (aged 19-83).
Klotho alleles (F and V) were genotyped using a Taqman assay.
Statistical analysis adjusted for age and body mass index.

Main Results:

The F allele frequency was 85%, and the V allele was 15%.
Younger/middle-aged men (age < 53) with FV/VV genotypes showed higher BMD at the lumbar spine, hip, and calcaneus compared to FF genotype.
Klotho genotype explained 2-4% of BMD variance but showed no association in older men.

Conclusions:

Klotho allelic variants are a significant genetic factor influencing BMD in adult men.
The association between Klotho genotype and BMD is age-dependent, primarily affecting younger and middle-aged individuals.
Further research is needed to fully elucidate Klotho's mechanism in male bone health.