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[Drugs affecting thyroid--part II].

Piotr Kucharczyk1, Dariusz Michałkiewicz, Aleksandra Kucharczyk

  • 1Wojskowy Instytut Medyczny w Warszawie, Szpitalny Oddzial Ratunkowy CSK MON. pkuch@mediclub.pl

Polski Merkuriusz Lekarski : Organ Polskiego Towarzystwa Lekarskiego
|January 9, 2007
PubMed
Summary

Certain medications and diagnostic agents can cause thyroid dysfunction, not just amiodarone. This review covers commonly used drugs like lithium, psychiatric medications, and iodinated agents, highlighting their impact on thyroid health.

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Area of Science:

  • Endocrinology
  • Pharmacology

Context:

  • Medications and diagnostic agents are frequently implicated in causing thyroid dysfunction.
  • Amiodarone is a well-known culprit, but other agents are often overlooked.
  • Understanding these drug-induced thyroid dysfunctions is crucial for patient care.

Purpose:

  • To review common medications and diagnostic agents that can induce thyroid dysfunction.
  • To discuss the mechanisms of thyroid toxicity for agents like lithium and psychiatric drugs.
  • To present updated European guidelines on iodinated contrast agents and their thyroid impact.

Summary:

  • This review details various medications and diagnostic agents, beyond amiodarone, that can lead to thyroid dysfunction.
  • It covers iodinated agents, lithium, psychiatric drugs, and cytokines, discussing their mechanisms and clinical relevance.

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  • Recent European guidelines for iodinated contrast agents are also included.

    • Impact:

    • Highlights the importance of considering drug-induced thyroid dysfunction in clinical practice.
    • Provides a comprehensive overview for healthcare professionals managing patients on potentially thyroid-toxic medications.
    • Emphasizes the need for awareness regarding agents used in long-term therapy, including in pediatric populations.