Related Experiment Video
Updated: Jul 17, 2026
Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
Published on: April 23, 2021
Use of Hachinski Ischemic Score in the memory clinic: Thai experience
Sasitorn Siritho1, Vorapun Senanarong, Arpas Nako
1Division of Neurology, Department of Medicine, Faculty of Medicine, Siriraj Hopital, Mahidol University, Bangkok, Thailand.
Background:
The validity ofHachinski Ischemic Score (HIS) in differentiating between Alzheimer's disease (AD) and Vascular dementia (VaD) has been questioned and compared with the gold standard autopsy.
Objective:
To confirm that the HIS can be used to differentiate related VaD from AD in a Thai population.
Material And Method:
A prospective study of 398 patients who were attending the Memory Clinic, at Siriraj Hospital between January 2001 and October 2003.
Results:
The 214 patients, with a mean age of 71.15 + 10.20 years, were classified as AD, VaD or mixed dementia (AD with cerebrovascular disease) in proportion of 60.2%, 30.4%, and 9.3% respectively. The authors propose HIS at 5 as a cut off point to differentiate patients with AD and those with VaD or AD with cerebrovascular disease with sensitivity of 85.3% and specificity of 72.9%.
Conclusion:
The HIS can be applied to differentiate dementia related vascular etiology from AD in a Thai population.
