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Related Experiment Video

Updated: Jul 17, 2026

Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation

Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation

Published on: July 9, 2014

[Varicella: previously healthy children sometimes develop complications].

M E Mérelle¹, L F A Visser, J A Bokma

¹Spaarne Ziekenhuis, afd. Kindergeneeskunde, Postbus 770, 2130 AT Hoofddorp.

Nederlands Tijdschrift Voor Geneeskunde

|January 9, 2007

Summary

Severe complications like bacterial infections and ataxia can follow chickenpox in children. Vaccination against varicella-zoster virus (VZV) is recommended in Europe and should be considered for national programs.

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Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation

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Area of Science:

Pediatrics
Infectious Diseases
Vaccinology

Background:

Varicella (chickenpox) can lead to severe complications in healthy children, including neurological issues and secondary bacterial infections.
European studies indicate varicella complications occur in 2.5% of healthy children.
A European consensus recommends routine varicella-zoster virus (VZV) vaccination for all children.

Observation:

Three healthy boys experienced severe complications (bacterial skin infection, cerebellar ataxia, pneumonia) one week after varicella onset.
The boys recovered fully after medical treatment.
The Netherlands has not yet implemented routine VZV vaccination.

Findings:

Varicella can present with serious, diverse complications in pediatric populations.
Prompt medical intervention can lead to complete recovery from severe varicella complications.
The incidence of varicella complications underscores the need for preventative measures.

Implications:

The findings support the European recommendation for routine VZV vaccination in children.
This case series suggests a need to reconsider the inclusion of VZV vaccination in the Dutch national immunization program.
Widespread VZV vaccination could reduce the burden of severe varicella-related morbidity in children.