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Related Concept Videos

SI Units: 2019 Redefinition01:13

SI Units: 2019 Redefinition

Measurement is an indispensable part of analytical chemistry. The result of measurement helps quantify a substance's physical property and compare it with the physical property of another substance. Each measurement comprises two components - a number indicating the magnitude and a unit of measurement as a standard for comparison. Further, the same quantity can be measured using different units of measurement, which leads to differences in magnitude.
A standard set of units has been defined to...
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Therapeutic Index

The therapeutic index of a drug is a key parameter in pharmacology that quantifies the relative safety of a drug by calculating the ratio between the dose that causes toxicity in half the population (50%) to the dose that proves to be effective for half the population (50%). It provides a spectrum of doses for a particular drug ranging from effective to potentially toxic. To illustrate, consider an anticoagulant agent like warfarin. It possesses a narrow window within its therapeutic index to...
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Antiprotozoal Agents

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Critical Region, Critical Values and Significance Level01:16

Critical Region, Critical Values and Significance Level

The critical region, critical value, and significance level are interdependent concepts crucial in hypothesis testing.
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Improving CRISPR-Cas9 Screens in CAR T Cells: A Refined Method for Library Preparation
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Improving CRISPR-Cas9 Screens in CAR T Cells: A Refined Method for Library Preparation

Published on: January 2, 2026

Improvements to the Red List Index.

Stuart H M Butchart1, H Resit Akçakaya, Janice Chanson

  • 1BirdLife International, Cambridge, United Kingdom. stuart.butchart@birdlife.org

Plos One
|January 9, 2007
PubMed
Summary

The Red List Index (RLI) tracks species extinction risk but has flaws. A revised RLI formula improves accuracy for non-avian taxa and prevents bias from new assessments, enhancing biodiversity monitoring.

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Improving CRISPR-Cas9 Screens in CAR T Cells: A Refined Method for Library Preparation
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Improving CRISPR-Cas9 Screens in CAR T Cells: A Refined Method for Library Preparation

Published on: January 2, 2026

Area of Science:

  • Conservation Biology
  • Ecology
  • Biodiversity Science

Background:

  • The Red List Index (RLI) is crucial for monitoring global biodiversity targets.
  • The RLI assesses trends in extinction risk for various species groups.
  • Previous RLI applications revealed limitations, particularly for non-avian taxa.

Purpose of the Study:

  • To address shortcomings in the original Red List Index formula.
  • To propose a revised RLI formula and application guidelines.
  • To enhance the accuracy and reliability of extinction risk trend assessments.

Main Methods:

  • Analysis of the original Red List Index formula and its performance.
  • Development of a revised RLI calculation method.
  • Testing the revised formula with simulated and real-world data (details not provided in abstract).

Main Results:

  • The revised RLI formula corrects issues with zero values and assessment frequency.
  • The new approach mitigates bias introduced by newly evaluated species.
  • Assessment errors are no longer propagated through time with the revised RLI.

Conclusions:

  • The proposed RLI revision offers a more robust method for tracking extinction risk trends.
  • This improved index enhances the assessment of progress towards biodiversity conservation goals.
  • The revised RLI provides a clearer picture of overall extinction risk levels and their changes over time.