Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Wingless directly represses DPP morphogen expression via an armadillo/TCF/Brinker complex.

Heidi Theisen1, Adeela Syed, Baochi T Nguyen

  • 1Department of Developmental and Cell Biology, University of California Irvine, Irvine, California, United States of America.

Plos One
|January 9, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Simulation-Based Training of Surgical and Nonsurgical Skills in Orthopaedic Residency (Symposium Presented at the 2024 Summer CORD Conference).

JB & JS open access·2025
Same author

Fracture liaison service evaluation during admission for fragility femur fracture increases rates of bone health intervention and outpatient follow-up.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2025
Same author

Identification and characterization of short-chain dehydrogenase/reductase 3 (DHRS3) deficiency, a retinoic acid embryopathy of humans.

Genetics in medicine open·2025
Same author

Prehabilitation Program for Lung and Esophageal Cancers (Boosting Recovery and Activity Through Early Wellness): Protocol for a Nonrandomized Trial.

JMIR research protocols·2025
Same author

Food Insecurity Is Common in the Orthopaedic Trauma Population.

The Journal of the American Academy of Orthopaedic Surgeons·2025
Same author

Proteome-wide analysis reveals G protein-coupled receptor-like proteins in rice (<i>Oryza sativa</i>).

Plant signaling & behavior·2024
Same journal

Epidemiological characteristics of amebiasis in Japan from 2001 to 2022.

PloS one·2026
Same journal

Longitudinal associations of academic stress with eating related patterns, nutrition, somatic indicators, and depressive symptoms in university students: A study protocol.

PloS one·2026
Same journal

Pollution removal efficiency enhancement by agricultural biomass additions in constructed wetlands: A framework integrating meta-analysis with explainable machine learning.

PloS one·2026
Same journal

Insulation failure mapping on power transformer bushing using FRA and electrostatic simulation.

PloS one·2026
Same journal

Enhancing medical Q&A systems with multimodal knowledge graphs and dual-layer attention mechanisms.

PloS one·2026
Same journal

UAMP: Consistent video object segmentation with uncertainty-aware memory propagation.

PloS one·2026
See all related articles

Wingless (WG) directly represses Decapentaplegic (DPP) gene transcription in Drosophila leg development. This novel repression mechanism, involving armadillo (ARM) and dTCF, maintains distinct morphogen territories for robust pattern formation.

Area of Science:

  • Developmental Biology
  • Molecular Genetics
  • Drosophila melanogaster research

Background:

  • Patterning and regeneration rely on spatially restricted morphogen expression.
  • Drosophila leg disc patterning involves dorsal DPP and ventral wingless (WG) expression.
  • The feedback loops controlling these patterns were known, but direct interactions were unclear.

Purpose of the Study:

  • To elucidate the mechanism of mutual repression between WG and DPP in Drosophila leg disc patterning.
  • To determine if WG directly regulates DPP expression.
  • To identify the molecular components involved in this regulatory interaction.

Main Methods:

  • Analysis of reporter gene expression patterns in regulatory DNA.
  • Utilizing different genetic backgrounds in Drosophila.

Related Experiment Videos

  • Investigating the role of WG mediators armadillo (ARM) and dTCF, and co-repressor Brinker (BRK).

    • Main Results:

    • Wingless (WG) was shown to directly repress the transcription of the Decapentaplegic (DPP) gene in the ventral leg disc.
    • DPP repression requires a complex of ARM, dTCF, and BRK binding to independent sites in the DPP locus.
    • This identifies a key component of the self-organizing system controlling morphogen expression.

    Conclusions:

    • This study reveals a novel mode of WG-mediated repression.
    • Signal-driven repression requiring both ARM and dTCF binding is a newly reported mechanism.
    • Direct regulation between morphogen pathways contributes to a robust self-organizing system for maintaining morphogen territories.