Related Experiment Video
Updated: Jul 17, 2026

Examining Proteasome Assembly with Recombinant Archaeal Proteasomes and Nondenaturing PAGE: The Case for a Combined Approach
Published on: December 17, 2016
Protein architecture chronology deduced from structures of amino acid synthases
1Shandong Provincial Research Center for Bioinformatic Engineering and Technique, Center for Advanced Study, Shandong University of Technology, Zibo 255049, P. R. China.
Abstract:
Inferring the protein architecture chronology is one of central topics in origin of life study and has been given much attention. Based on an amino acid evolutionary model that late amino acids were bio-synthesized prior to early counterparts, we addressed the issue by examining the structures of amino acid synthases. Despite the limited structural information on amino acid synthases, our deduction revealed that alpha/beta was the oldest protein class, which is in good agreement with the prior fold-usage-based conclusion.
Related Concept Videos
Protein Organization
Protein Organization
The primary structure of a protein is its amino acid sequence.
Protein Organization
Protein Organization
The primary structure of a protein is its amino acid sequence.
Protein and Protein Structure
A protein's shape is critical to its function. For example, an enzyme can...
Protein Folding

